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LOBICO Best Models

Best CV model Single model DataSet Cancer Drug Drug Id CV Error Action(s)
¬AHNAK & ¬RB1 & ¬a(GATA3,KLF6,LARP4B,VIM) & ¬a6p22.3   a(ASXL1) GDSC BLCA AZD6244 1498 0.3828
CDKN2A | IREB2 | a3p25.2 | MAPK_PI3K-UP   MAPK_PI3K-UP GDSC BLCA Bleomycin__50_uM 1378 0.19291
¬ARID1A & ¬NF2 & ¬a(ASXL1)   SMARCA4 GDSC BLCA CX-5461 300 0.27846
ANK3 | FAT1 | NCOR1 | d13q14.2   d13q14.2 GDSC BLCA FTI-277 166 0.5
a3p25.2   a3p25.2 GDSC BLCA GSK690693 326 0.5
TP53 & ¬d(FAT1,IRF2) & ¬a(SDHC) & ¬MAPK_PI3K-UP   MLL3 GDSC BLCA OSU-03012 167 0.29415
ANK3 | MLL3 | NCOR2 | a3p25.2   ANK3 GDSC BLCA RO-3306 1052 0.52199
SMARCA4   SMARCA4 GDSC BLCA rTRAIL 1261 0.5
SMARCA4   SMARCA4 GDSC OV CX-5461 300 0.52115
ANK3 | d(CHD9,CNOT1,CYLD,MMP2,NUP93)   d(CHD9,CNOT1,CYLD,MMP2,NUP93) GDSC BLCA SB_216763 1025 0.081578
¬ARID1A & ¬RB1 & ¬a(ASXL1)   AHNAK GDSC BLCA Tubastatin_A 265 0.33911
¬a18p11.32 & a(MYC) | CDKN1A & ¬MAPK_only-UP   ANK3 GDSC BLCA Y-39983 309 0.53696
d(STK11) | d13q14.2 | a(BLM,CRTC3,FANCI,IDH2,NR2F2,PCSK6) | IL-1-UP   d4p15.2 GDSC BRCA ABT-263 1011 0.31407
¬ASXL2 & a(CDK12,ERBB2,MED24) & ¬PI3K_only-UP   a(CDK12,ERBB2,MED24) GDSC BRCA Afatinib 1032 0.16119
a(CDK12,ERBB2,MED24)   a(CDK12,ERBB2,MED24) GDSC BRCA Afatinib__rescreen 1377 0.022946
a(CDK12,ERBB2,MED24)   a(CDK12,ERBB2,MED24) GDSC BRCA CP724714 255 0.057861
a(CDK12,ERBB2,MED24)   a(CDK12,ERBB2,MED24) GDSC BRCA Lapatinib 119 0.003855
a(CDK12,ERBB2,MED24)   a(CDK12,ERBB2,MED24) GDSC PANCAN CP724714 255 0.31708
a(FGFR1,WHSC1L1) & d(FAT1,IRF2)   d13q14.2 GDSC BRCA AICAR 1001 0.51308
ARID1A | a(GATA3,KLF6,LARP4B,VIM)   a(GATA3,KLF6,LARP4B,VIM) GDSC BRCA AKT_inhibitor_VIII 171 0.44746
ASH1L | ASPM | MLL3 | a(KRAS)   a(CLTC,PPM1D) GDSC BRCA AS601245 207 0.4695
¬CDH1 & ¬a(TERT) & a(RAD21) & ¬d(SYNCRIP,ZNF292)   a(CLTC,PPM1D) GDSC BRCA ATRA 1009 0.1334
ARID1A | CHD4 | EIF4A2 | a(FOXA1,NKX2-1,PSMA6)   a(FOXA1,NKX2-1,PSMA6) GDSC BRCA AZD6482 1066 0.39267
FLT3 | PTEN | d19p12 | VEGF-UP   a(EGFR) GDSC BRCA BIRB_0796 1042 0.53403
ASH1L | a6p24.2   ASH1L GDSC BRCA Bleomycin 190 0.31987
d19p12 | VEGF-UP   d19p12 GDSC BRCA BMS-708163 1072 0.20161
¬a(RAD21) & ¬d(SYNCRIP,ZNF292) & ¬a(CDK12,ERBB2,MED24)   a(KRAS) GDSC BRCA Bryostatin_1 197 0.48357
¬a(MDM2,NUP107) & ¬a(TERT) & a8q24.21 & ¬H2O2-DOWN   d19p12 GDSC BRCA CCT007093 1067 0.4424
CDH1 | CHD4 | KRAS | a(EGFR)   d(ARID1B,MAP3K4,MLLT4) GDSC BRCA CH5424802 281 0.47566
BRCA2   BRCA2 GDSC BRCA CHIR-99021 1241 0.13549
¬a6p24.2 & ¬d(SYNCRIP,ZNF292) & ¬a(CDK12,ERBB2,MED24) & ¬d(PABPC3,SACS,ZMYM2)   a1q21.3 GDSC BRCA CX-5461 300 0.41443
¬a(KRAS) & ¬a(FGFR1,WHSC1L1) & a(CDK12,ERBB2,MED24)   a(CLTC,PPM1D) GDSC BRCA EKB-569 282 0.15788
¬ARID1A & ¬d8p23.2 & ¬d(FAT1,IRF2) & ¬a1q21.3   a(CLTC,PPM1D) GDSC BRCA FH535 173 0.42723
a(RAD21) & ¬a8q24.21   ARID1B GDSC BRCA GSK-1904529A 202 0.30589
PTEN & d(FAT1,IRF2) | a(FGFR1,WHSC1L1) & ¬a(SDHC)   MACF1 GDSC BRCA GSK269962A 1192 0.53115
PIK3CA   PIK3CA GDSC BRCA GSK690693 326 0.35179
PIK3CA   PIK3CA GDSC OV GSK690693 326 0.021899
¬a(FGFR1,WHSC1L1) & a(RAD21) & ¬a(EGFR)   CHD4 GDSC BRCA GW-2580 193 0.14587
BAP1   BAP1 GDSC BRCA GW_441756 1023 0.5
a(CLTC,PPM1D) & ¬d(FAT1,IRF2) | a8q24.21 & d8p23.2   a(CLTC,PPM1D) GDSC BRCA KIN001-102 228 0.44089
¬d(FAS,PTEN) & ¬a(FGFR1,WHSC1L1) & d8p23.3   d8p23.3 GDSC BRCA LFM-A13 192 0.36552
CUX1 | ZFP36L1 | a1q21.3   CUX1 GDSC BRCA LY317615 229 0.49474
¬BRCA1 & TP53 & ¬d(SYNCRIP,ZNF292) & ¬d(FAT1,IRF2)   APC GDSC BRCA MK-2206 1053 0.53219
GATA3 | MGA | POLR2B | PI3K_only-UP   a(CLTC,PPM1D) GDSC BRCA MP470 293 0.25217
ASH1L   ASH1L GDSC BRCA NSC-87877 147 0.24314
ASH1L   ASH1L GDSC BRCA Shikonin 170 0.017621
PIK3CA & ¬a(FGFR1,WHSC1L1) & ¬d8p23.2 & ¬a20q13.2   AHNAK GDSC BRCA PF-4708671 1129 0.45697
a(CLTC,PPM1D)   a(CLTC,PPM1D) GDSC BRCA Phenformin 196 0.52914
d15q12   d15q12 GDSC BRCA PIK-93 303 0.47734
CHD4 | d13q14.2   CHD4 GDSC BRCA QL-XI-92 329 0.28375
PTEN & a(FOXA1,NKX2-1,PSMA6) | PIK3CA & a(CLTC,PPM1D)   a(CLTC,PPM1D) GDSC BRCA QL-XII-61 1203 0.3077
APC | ATR | d19p12 | PI3K_only-DOWN   a(EGFR) GDSC BRCA RO-3306 1052 0.51189
a7q36.2   a7q36.2 GDSC BRCA rTRAIL 1261 0.38211
ATR | CHD4 | FAT1 | H2O2-DOWN   PI3K_only-UP GDSC BRCA SB52334 304 0.21337
¬TP53 & ¬a8q24.21 | a8q24.21 & PI3K_only-UP   PI3K_only-UP GDSC BRCA SL_0101-1 1039 0.50486
¬a(TERT) & a(RAD21) & ¬a20q13.2 & ¬a(CCND1)   PI3K_only-UP GDSC BRCA STF-62247 258 0.33185
PIK3CA & ¬a(FOXA1,NKX2-1,PSMA6)   a(CLTC,PPM1D) GDSC BRCA Tipifarnib 204 0.29802
MLL3   MLL3 GDSC BRCA TL-2-105 211 0.50813
¬BRCA1 & ¬d(SYNCRIP,ZNF292) & a1q21.3   a1q21.3 GDSC BRCA Tubastatin_A 265 0.39813
BAP1 | d8p23.3 | TGFB-DOWN   d8p23.3 GDSC BRCA WZ3105 252 0.16305
¬a(FOXA1,NKX2-1,PSMA6) & a1q21.3   a1q21.3 GDSC BRCA Y-39983 309 0.46292
BRWD1 | NCOR1 | d4q31.21 | a(MET)   a(MET) GDSC COREAD _5Z_-7-Oxozeaenol 1242 0.35639
ITSN1 | SMAD2 | SMAD4 | Wnt-DOWN   SMAD4 GDSC COREAD A-770041 55 0.27524
a(HSP90AB1,TRERF1) | a20p11.21 | a8p11.21 | a(MET)   a(MET) GDSC COREAD ABT-263 1011 0.3399
TCF7L2 | ZC3H11A | IL-1-DOWN   IL-1-DOWN GDSC COREAD AC220 254 0.24297
¬BRAF & ¬KRAS   d5q12.1 GDSC COREAD Afatinib 1032 0.42438
PTPRU | a11p15.5 | TNFa-UP | Wnt-DOWN   a11p15.5 GDSC COREAD Afatinib__rescreen 1377 0.49559
¬BMPR2 & d(SMAD4) | ¬PIK3CA & SMAD4   d(SMAD4) GDSC COREAD AS605240 224 0.3235
¬EGFR & ¬PIK3CA & ¬d(CDKN2A) & ¬VEGF-DOWN   BRAF GDSC COREAD AZD6244 1498 0.40854
KRAS & ¬SMAD4 & ¬d(CDKN2A) & ¬dXp21.3   ASXL2 GDSC COREAD Bleomycin 190 0.41405
¬CREBBP & ¬KRAS & d3p14.2   RNF43 GDSC COREAD BMS-536924 1091 0.38805
CHD9 | GNAS | PPP2R1A | d4q34.3   GNAS GDSC COREAD BMS-708163 1072 0.45147
CHD9 | TCF7L2 | a(FLT3,WASF3)   d(SMAD4) GDSC COREAD BMS-754807 184 0.45708
¬CREBBP & ¬a(ING1,IRS2,TFDP1) & ¬d8p21.1 & VEGF-DOWN   a11p15.5 GDSC COREAD Cetuximab 1114 0.41638
MLL2 & ¬dXp21.3   MLL2 GDSC COREAD CH5424802 281 0.14369
¬MLL2 & ¬PIK3CA & ¬a(CHD4,WNK1) & ¬d8p21.1   a(STK4) GDSC COREAD CI-1040 1015 0.34296
MLL2   MLL2 GDSC COREAD CX-5461 300 0.29906
MLL2   MLL2 GDSC PANCAN Cytarabine 1006 0.38929
MLL2   MLL2 GDSC PANCAN GDC0941 1058 0.46877
MLL2   MLL2 GDSC PANCAN OSI-027 299 0.38429
BRAF | CDC73   BRAF GDSC COREAD Dabrafenib 1373 0.051654
SOX9   SOX9 GDSC COREAD EKB-569 282 0.51582
MECOM | SMC1A | a(MYC)   SMARCA4 GDSC COREAD FR-180204 263 0.55332
¬B2M & MLL2 & ¬NR4A2   SMARCA4 GDSC COREAD GSK1070916 226 0.45967
PTEN   PTEN GDSC COREAD GSK690693 326 0.27906
PTEN   PTEN GDSC LUAD BMN-673 1259 0.50909
a8p11.21 | a(MYC) | d2p12   a(MYC) GDSC COREAD HG-5-88-01 1143 0.31841
SACS   SACS GDSC COREAD I-BET_151 275 0.28632
RNF43 | a(HSP90AB1,TRERF1)   RNF43 GDSC COREAD JNK-9L 157 0.18232
¬EP300 & ¬KRAS & ¬SMAD4   a20p11.21 GDSC COREAD JQ1 1218 0.34216
¬FBXW7 & ¬d(SMAD4) & d3p14.2   PI3K_only-UP GDSC COREAD KIN001-260 290 0.2648
MSR1 | RB1 | d4q31.21 | TGFB-DOWN   TRIO GDSC COREAD LY317615 229 0.42258
PBRM1   PBRM1 GDSC COREAD MP470 293 0.42567
PBRM1   PBRM1 GDSC KIRC GW_441756 1023 0.5694
CTNNB1 | ¬TP53 | Wnt-DOWN   CTNNB1 GDSC COREAD Nutlin-3a 1047 0.05626
¬APC & KRAS | ¬TP53 & a(MYC)   ¬APC GDSC COREAD NVP-BHG712 295 0.29498
¬BMPR2 & d3p14.2 & ¬VEGF-DOWN   a(FLT3,WASF3) GDSC COREAD OSI-906 185 0.14578
ITSN1 | a(HSP90AB1,TRERF1)   ITSN1 GDSC COREAD OSU-03012 167 0.13722
¬BMPR2 & ¬d(CDKN2A) & ¬VEGF-DOWN   a(ING1,IRS2,TFDP1) GDSC COREAD PD-0325901 1060 0.24935
¬KRAS & d(SMAD4)   EGFR GDSC COREAD PF-562271 158 0.5
TRIO   TRIO GDSC COREAD Phenformin 196 0.16577
BRAF & ¬dXp21.3 & d3p14.2   BRAF GDSC COREAD PLX4720 1036 0.091703
BRAF   BRAF GDSC COREAD PLX4720__rescreen 1371 0.07642
BRAF   BRAF GDSC PANCAN 17-AAG 1026 0.47996
BRAF   BRAF GDSC PANCAN Dabrafenib 1373 0.16409
BRAF   BRAF GDSC PANCAN PLX4720 1036 0.15294
BRAF   BRAF GDSC PANCAN PLX4720__rescreen 1371 0.16033
BRAF   BRAF GDSC PANCAN SB590885 1061 0.20692
DNMT3A | FN1 | FOXP1 | SRGAP3   FBXW7 GDSC COREAD QL-XII-61 1203 0.39588
¬EGFR & ¬PIK3CA & ¬d(CDKN2A) & ¬VEGF-DOWN   a(ING1,IRS2,TFDP1) GDSC COREAD RDEA119 1014 0.33747
¬B2M & ¬EP300 & ¬d(CDKN2A) & ¬d8p21.1   BRAF GDSC COREAD RDEA119__rescreen 1526 0.34
BRWD1 | ¬TP53   ¬TP53 GDSC COREAD rTRAIL 1261 0.3241
¬KRAS & ¬d8p21.1 & ¬dXp21.3 & ¬d(APC)   BRAF GDSC COREAD SB590885 1061 0.25042
d6q26 & d3p14.2 | TCF7L2 & ¬d(APC)   a(CHD4,WNK1) GDSC COREAD STF-62247 258 0.48772
BMPR2 & ¬SMARCA4   ARID1A GDSC COREAD Tipifarnib 204 0.44383
¬ATM & ¬B2M & ¬PIK3R1 & ¬d(CDKN2A)   ¬TP53 GDSC COREAD Trametinib 1372 0.39523
RNF43   RNF43 GDSC COREAD Tubastatin_A 265 0.46795
RNF43   RNF43 GDSC DLBC Methotrexate 1008 0.46081
¬CTCF & ¬d(CDKN2A) & ¬d(SMAD4) & ¬VEGF-DOWN   BRAF GDSC COREAD VX-11e 262 0.28207
¬MGA & SMAD4 & ¬a13q22.1   SMAD4 GDSC COREAD XMD14-99 253 0.40941
MLL2 & ¬d(APC)   SMARCA4 GDSC COREAD Y-39983 309 0.39496
¬ARID2 & ¬NR4A2 & RNF43   RNF43 GDSC COREAD ZM-447439 1050 0.31575
RNF43 | d16q23.1 | JAK-STAT-UP | Wnt-UP   Wnt-UP GDSC DLBC 5-Fluorouracil 179 0.2461
¬PTEN & TP53 & ¬d16q23.1 & ¬d15q15.1   TLR-UP GDSC DLBC A-770041 55 0.29847
¬PTEN & TP53 & ¬d16q23.1 & ¬JAK-STAT-UP   CREBBP GDSC DLBC ABT-263 1011 0.4432
¬MLL2 & TP53 & ¬MAPK_PI3K-DOWN   JAK-STAT-UP GDSC DLBC ABT-869 277 0.38023
¬MLL2 & ¬PTEN & TP53 & ¬TLR-UP   ASXL2 GDSC DLBC ABT-888 1018 0.23576
H2O2-DOWN | MAPK_only-DOWN   MAPK_only-DOWN GDSC DLBC AC220 254 0.49829
H2O2-DOWN | MAPK_only-DOWN   MAPK_only-DOWN GDSC DLBC NVP-BEZ235 1057 0.13405
ASXL2 | Wnt-UP   Wnt-UP GDSC DLBC AICAR 1001 0.35625
CREBBP & ¬d15q15.1 & ¬IL-1-DOWN   CREBBP GDSC DLBC AP-24534 155 0.34896
ASXL2 | MYC | H2O2-DOWN | MAPK_only-DOWN   PTEN GDSC DLBC AR-42 272 0.42699
JAK-STAT-UP | MAPK_only-DOWN   MAPK_only-DOWN GDSC DLBC AT-7519 219 0.46466
MYC | PTEN   MYC GDSC DLBC ATRA 1009 0.079616
ASXL2   ASXL2 GDSC DLBC AV-951 312 0.5
¬ARID1A & CREBBP   CREBBP GDSC DLBC AZD-0530 38 0.42352
¬ARID1A & CREBBP   CREBBP GDSC DLBC CMK 64 0.4357
EP300 | MAPK_only-DOWN   MAPK_only-DOWN GDSC DLBC AZD6482 1066 0.25503
MYC | MAPK_only-DOWN   MAPK_only-DOWN GDSC DLBC AZD7762 1022 0.33029
MAPK_only-DOWN   MAPK_only-DOWN GDSC DLBC AZD8055 1059 0.30861
MAPK_only-DOWN   MAPK_only-DOWN GDSC DLBC IPA-3 176 0.56686
MAPK_only-DOWN   MAPK_only-DOWN GDSC DLBC KU-55933 1030 0.53741
MAPK_only-DOWN   MAPK_only-DOWN GDSC DLBC LY317615 229 0.20526
MAPK_only-DOWN   MAPK_only-DOWN GDSC DLBC Nilotinib 1013 0.27999
MAPK_only-DOWN   MAPK_only-DOWN GDSC DLBC Vismodegib 1033 0.21041
MAPK_only-DOWN   MAPK_only-DOWN GDSC DLBC ZSTK474 223 0.37801
CREBBP & ¬d15q15.1 | ¬TP53 & Wnt-UP   MAPK_only-DOWN GDSC DLBC BAY_61-3606 178 0.17956
Wnt-UP   Wnt-UP GDSC DLBC Bicalutamide 1502 0.42476
Wnt-UP   Wnt-UP GDSC DLBC Camptothecin 1003 0.42028
Wnt-UP   Wnt-UP GDSC DLBC Embelin 172 0.29471
Wnt-UP   Wnt-UP GDSC DLBC KIN001-270 345 0.45828
Wnt-UP   Wnt-UP GDSC OV rTRAIL 1261 0.56283
MLL2 & ¬d(CDKN2A) | ¬TP53 & ¬d(CDKN2A)   d10p12.2 GDSC DLBC BIRB_0796 1042 0.38021
Wnt-UP & ¬MAPK_only-DOWN | CREBBP & ¬TP53   Wnt-UP GDSC DLBC BIX02189 279 0.55073
EP300   EP300 GDSC DLBC BMS-345541 203 0.43239
EP300   EP300 GDSC PAAD FR-180204 263 0.56541
EP300   EP300 GDSC SKCM Bosutinib 1019 0.5
¬MLL2 & ¬d16q23.1 & ¬TLR-UP & ¬MAPK_PI3K-DOWN   ASXL2 GDSC DLBC BMS-708163 1072 0.43961
¬MLL2 & ¬PTEN & TP53 & ¬JAK-STAT-UP   MAPK_only-DOWN GDSC DLBC Bosutinib 1019 0.18384
CREBBP & d(CDKN2A) | MLL2 & TP53   Wnt-UP GDSC DLBC Bryostatin_1 197 0.59222
RNF43 | MAPK_only-DOWN   MAPK_only-DOWN GDSC DLBC BX-795 1037 0.46617
ARID1A | EP300 | MYC | MAPK_only-DOWN   Wnt-UP GDSC DLBC BX-912 222 0.51581
EP300 | Wnt-UP   EP300 GDSC DLBC CAL-101 238 0.16505
MLL2 | H2O2-DOWN   MLL2 GDSC DLBC CAY10603 276 0.32909
¬ARID1A & ¬MLL2 & TP53 & ¬TLR-UP   ASXL2 GDSC DLBC CCT007093 1067 0.22679
¬EP300 & MAPK_only-DOWN & ¬PI3K_only-DOWN   MAPK_only-DOWN GDSC DLBC CEP-701 1024 0.50503
B2M   B2M GDSC DLBC CGP-082996 54 0.5
B2M   B2M GDSC DLBC JQ1 1218 0.5
¬CREBBP & ¬TP53 & ¬d16q23.1 & ¬TLR-UP   Wnt-UP GDSC DLBC CH5424802 281 0.29775
¬CREBBP & ¬TP53 & ¬d16q23.1 & ¬TLR-UP   Wnt-UP GDSC DLBC piperlongumine 1243 0.22932
d15q15.1 | Wnt-UP   d15q15.1 GDSC DLBC CHIR-99021 1241 0.5449
d15q15.1 | Wnt-UP   d15q15.1 GDSC DLBC UNC0638 1236 0.42776
B2M | CREBBP | Wnt-UP | H2O2-DOWN   Wnt-UP GDSC DLBC CP466722 152 0.47413
¬EP300 & ¬MLL2 & ¬d16q23.1 & ¬TLR-UP   Wnt-UP GDSC DLBC CP724714 255 0.32655
ASXL2 | MLL2 | H2O2-DOWN   MLL2 GDSC DLBC CUDC-101 273 0.35447
¬ARID1A & CREBBP & ¬d(CIITA) & ¬d15q15.1   CREBBP GDSC DLBC Cyclopamine 17 0.41535
MLL2 | RNF43   MLL2 GDSC DLBC Cytarabine 1006 0.27537
¬TP53 & ¬TLR-UP & ¬MAPK_PI3K-DOWN   Wnt-UP GDSC DLBC Dabrafenib 1373 0.35808
¬TP53 & ¬TLR-UP & ¬MAPK_PI3K-DOWN   Wnt-UP GDSC DLBC XMD15-27 332 0.41322
CREBBP   CREBBP GDSC DLBC Dasatinib 51 0.281
d16q23.1 | Wnt-UP | H2O2-DOWN   Wnt-UP GDSC DLBC DMOG 165 0.34898
d(CDKN2A) & ¬TLR-UP | ASXL2   d(CDKN2A) GDSC DLBC EKB-569 282 0.49571
¬MLL2 & ¬PTEN & ¬TLR-UP & ¬MAPK_PI3K-DOWN   B2M GDSC DLBC Erlotinib 1 0.27965
¬TP53 & ¬d16q23.1 & ¬TLR-UP & ¬PI3K_only-DOWN   d(CDKN2A) GDSC DLBC Etoposide 134 0.38371
ASXL2 | JAK-STAT-UP | Wnt-UP | H2O2-DOWN   Wnt-UP GDSC DLBC EX-527 341 0.36938
ARID1A | EP300 | JAK-STAT-UP | Wnt-UP   MAPK_only-DOWN GDSC DLBC FMK 231 0.18752
MAPK_only-DOWN & ¬PI3K_only-DOWN   MAPK_only-DOWN GDSC DLBC GDC0941 1058 0.26539
¬MLL2 & ¬PTEN & ¬d16q23.1 & ¬TLR-UP   ASXL2 GDSC DLBC GNF-2 52 0.050941
ARID1A | MYC | PTEN   MLL2 GDSC DLBC GSK1070916 226 0.57557
¬MLL2 & ¬PTEN & ¬TLR-UP & ¬MAPK_PI3K-DOWN   ASXL2 GDSC DLBC GSK-1904529A 202 0.16456
ASXL2 | EP300 | Wnt-UP   EP300 GDSC DLBC GSK2126458 283 0.40988
ASXL2 | EP300 | Wnt-UP   EP300 GDSC DLBC PI-103 302 0.42633
¬TP53 & ¬d(CDKN2A) | ¬EP300 & MAPK_only-DOWN   MAPK_only-DOWN GDSC DLBC GSK269962A 1192 0.32797
MYC | Wnt-UP | H2O2-DOWN | MAPK_PI3K-DOWN   MAPK_PI3K-DOWN GDSC DLBC GSK429286A 230 0.47532
¬TP53 & ¬d10p12.2 & ¬MAPK_PI3K-DOWN   d16q23.1 GDSC DLBC GW-2580 193 0.39996
¬CREBBP & TLR-UP | MLL2 & d(CDKN2A)   MYC GDSC DLBC GW_441756 1023 0.51759
H2O2-DOWN & ¬IL-1-DOWN   H2O2-DOWN GDSC DLBC HG-6-64-1 159 0.5
EP300 & ¬d(CIITA) | ¬TP53 & ¬TLR-UP   MLL2 GDSC DLBC I-BET_151 275 0.34386
¬ARID1A & CREBBP   d15q15.1 GDSC DLBC IOX2 1230 0.28218
¬CREBBP & ¬PTEN & TP53 & ¬TLR-UP   MAPK_only-DOWN GDSC DLBC JNK_Inhibitor_VIII 1043 0.40103
ASXL2 | Wnt-UP | H2O2-DOWN   H2O2-DOWN GDSC DLBC JQ12 164 0.53778
ASXL2 & ¬RNF43 | EP300   EP300 GDSC DLBC JW-7-24-1 256 0.35367
¬d(CDKN2A) & Wnt-UP | EP300 & ¬IL-1-DOWN   EP300 GDSC DLBC KIN001-102 228 0.1372
¬MLL2 & ¬d16q23.1 & ¬TLR-UP & ¬MAPK_PI3K-DOWN   MAPK_only-DOWN GDSC DLBC KIN001-135 91 0.42299
¬d16q23.1 & ¬d(CDKN2A) & ¬d15q15.1 & ¬TLR-UP   MAPK_only-DOWN GDSC DLBC KIN001-236 286 0.42287
¬RNF43 & TP53 & ¬H2O2-DOWN & ¬MAPK_PI3K-DOWN   MAPK_only-DOWN GDSC DLBC KIN001-244 287 0.43138
MLL2 | Wnt-UP   MLL2 GDSC DLBC KIN001-260 290 0.3386
d16q23.1 | MAPK_only-DOWN   MAPK_only-DOWN GDSC DLBC LAQ824 200 0.54106
¬MLL2 & ¬PTEN & ¬TLR-UP   d16q23.1 GDSC DLBC Lenalidomide 1020 0.17356
¬ARID1A & d16q23.1   d16q23.1 GDSC DLBC LFM-A13 192 0.51618
ARID1A   ARID1A GDSC DLBC Masitinib 292 0.50234
ARID1A   ARID1A GDSC OV MK-2206 1053 0.07011
PTEN & ¬MAPK_only-DOWN | MAPK_only-DOWN & ¬PI3K_only-DOWN   MAPK_only-DOWN GDSC DLBC MK-2206 1053 0.27831
¬TP53 & ¬TLR-UP   d(CDKN2A) GDSC DLBC MP470 293 0.175
¬TP53 & ¬TLR-UP   d(CDKN2A) GDSC DLBC TPCA-1 305 0.47557
¬MLL2 & ¬TP53 & ¬TLR-UP   JAK-STAT-UP GDSC DLBC MS-275 88 0.17574
MAPK_only-DOWN | ¬d10p12.2 & Wnt-UP   MAPK_only-DOWN GDSC DLBC NG-25 260 0.23106
¬EP300 & PTEN | MLL2 & ¬MAPK_PI3K-DOWN   RNF43 GDSC DLBC NPK76-II-72-1 257 0.45859
¬MLL2 & ¬d16q23.1 & ¬TLR-UP & ¬MAPK_only-DOWN   d15q15.1 GDSC DLBC NSC-87877 147 0.18762
EP300 | MYC | d15q15.1 | MAPK_only-DOWN   MAPK_only-DOWN GDSC DLBC NU-7441 1038 0.41105
¬TP53   ¬TP53 GDSC DLBC Nutlin-3a 1047 0.052532
¬TP53   ¬TP53 GDSC LAML Nutlin-3a 1047 0.030576
¬TP53   ¬TP53 GDSC LAML NVP-BHG712 295 0.19597
¬TP53   ¬TP53 GDSC LUAD AZD6244 1498 0.33328
¬TP53   ¬TP53 GDSC LUAD Nutlin-3a 1047 0.13633
¬TP53   ¬TP53 GDSC OV Nutlin-3a 1047 0.12497
ASXL2 | Wnt-UP | MAPK_only-DOWN   MAPK_only-DOWN GDSC DLBC NVP-BHG712 295 0.39713
ASXL2 | Wnt-UP | MAPK_only-DOWN   MAPK_only-DOWN GDSC DLBC TL-1-85 261 0.23617
ARID1A | ASXL2 | B2M | Wnt-UP   Wnt-UP GDSC DLBC Olaparib 1495 0.37429
ASXL2 | MLL2   MLL2 GDSC DLBC OSI-027 299 0.35518
ASXL2 | Wnt-UP | H2O2-DOWN | MAPK_PI3K-DOWN   MAPK_PI3K-DOWN GDSC DLBC OSI-930 298 0.44514
ARID1A | d16q23.1 | Wnt-UP   Wnt-UP GDSC DLBC PAC-1 175 0.4364
¬TP53 & ¬d16q23.1 & ¬TLR-UP & ¬IL-1-DOWN   MAPK_only-DOWN GDSC DLBC Parthenolide 89 0.36532
¬MLL2 & ¬PTEN & ¬TLR-UP & ¬MAPK_PI3K-DOWN   d16q23.1 GDSC DLBC PD-173074 1049 0.26992
H2O2-DOWN | ¬TP53 & ¬TLR-UP   Wnt-UP GDSC DLBC PFI-1 1219 0.39605
¬TP53 & ¬TLR-UP | EP300   Wnt-UP GDSC DLBC PHA-793887 301 0.36628
¬d16q23.1 & Wnt-UP | MLL2 & MAPK_PI3K-DOWN   Wnt-UP GDSC DLBC Phenformin 196 0.16406
TP53 & ¬d16q23.1 & ¬d15q15.1 & ¬IL-1-DOWN   EP300 GDSC DLBC PIK-93 303 0.2972
d16q23.1 | Wnt-UP   d16q23.1 GDSC DLBC PLX4720__rescreen 1371 0.36574
¬CREBBP & ¬PTEN & TP53 & ¬d16q23.1   MLL2 GDSC DLBC PXD101_Belinostat 274 0.33885
MLL2 & ¬d16q23.1 & ¬d10p12.2   ASXL2 GDSC DLBC QL-X-138 331 0.2952
d(CDKN2A) | MAPK_only-DOWN   d(CDKN2A) GDSC DLBC QL-XI-92 329 0.473
¬PTEN & TP53 & ¬d15q15.1   B2M GDSC DLBC Rapamycin 3 0.37383
¬CREBBP & ¬MLL2 & ¬PTEN & ¬TLR-UP   B2M GDSC DLBC Roscovitine 110 0.33043
¬CREBBP & ¬PTEN & TP53   Wnt-UP GDSC DLBC rTRAIL 1261 0.22439
¬MLL2 & ¬TLR-UP & ¬MAPK_only-DOWN & ¬MAPK_PI3K-DOWN   Wnt-UP GDSC DLBC Ruxolitinib 206 0.48142
¬PTEN & ¬d(CIITA) & MAPK_only-DOWN & ¬PI3K_only-DOWN   MAPK_only-DOWN GDSC DLBC SB_216763 1025 0.16437
¬MLL2 & ¬RNF43 & ¬TLR-UP & ¬MAPK_PI3K-DOWN   Wnt-UP GDSC DLBC SB-505124 1194 0.32765
MLL2 & d(CDKN2A) | PTEN & ¬TP53   d(CDKN2A) GDSC DLBC SB52334 304 0.19813
d10p12.2 & ¬TLR-UP   MYC GDSC DLBC SB590885 1061 0.52989
¬CREBBP & ¬MLL2 & ¬d16q23.1 & ¬TLR-UP   EP300 GDSC DLBC SGC0946 1264 0.32834
MYC | d(CIITA) | Wnt-UP | H2O2-DOWN   H2O2-DOWN GDSC DLBC Shikonin 170 0.54101
¬PTEN & TP53 & ¬d16q23.1 & ¬TLR-UP   MAPK_only-DOWN GDSC DLBC SL_0101-1 1039 0.36666
RNF43 | Wnt-UP | H2O2-DOWN | MAPK_only-DOWN   Wnt-UP GDSC DLBC STF-62247 258 0.35589
¬CREBBP & ¬TP53 & ¬TLR-UP   MYC GDSC DLBC T0901317 333 0.3682
JAK-STAT-UP | H2O2-DOWN | MAPK_only-DOWN   H2O2-DOWN GDSC DLBC TAK-715 221 0.53282
CREBBP & ¬d(CIITA) & ¬IL-1-DOWN & ¬PI3K_only-DOWN   CREBBP GDSC DLBC Tamoxifen 1199 0.41658
RNF43 | d16q23.1 | Wnt-UP   d16q23.1 GDSC DLBC Temozolomide 1375 0.33128
d15q15.1 | MAPK_only-DOWN   MAPK_only-DOWN GDSC DLBC Temsirolimus 1016 0.24363
¬TP53 & ¬d10p12.2 & ¬TLR-UP & ¬PI3K_only-DOWN   Wnt-UP GDSC DLBC TG101348 306 0.35973
TP53 & TLR-UP | ARID1A & ¬MAPK_PI3K-DOWN   JAK-STAT-UP GDSC DLBC THZ-2-102-1 346 0.49402
ARID1A | MYC | d(CIITA) | JAK-STAT-UP   d(CDKN2A) GDSC DLBC THZ-2-49 344 0.50961
d16q23.1   d16q23.1 GDSC DLBC Tipifarnib 204 0.14071
d16q23.1   d16q23.1 GDSC SKCM CHIR-99021 1241 0.54002
CREBBP | H2O2-DOWN | MAPK_PI3K-DOWN   MAPK_PI3K-DOWN GDSC DLBC TL-2-105 211 0.59963
MLL2 | MAPK_only-DOWN   MLL2 GDSC DLBC Tubastatin_A 265 0.22662
MLL2 | MAPK_only-DOWN   MLL2 GDSC PANCAN Camptothecin 1003 0.31233
MLL2 | MAPK_only-DOWN   MLL2 GDSC PANCAN QL-X-138 331 0.34303
¬d16q23.1 & ¬d(CDKN2A) & ¬JAK-STAT-UP & ¬MAPK_PI3K-DOWN   Wnt-UP GDSC DLBC UNC1215 1262 0.45517
¬MLL2 & ¬TP53 & ¬TLR-UP   Wnt-UP GDSC DLBC Vinblastine 1004 0.57808
¬CREBBP & TP53 & ¬TLR-UP   Wnt-UP GDSC DLBC VNLG124 271 0.47125
ASXL2 | B2M | MYC   B2M GDSC DLBC Vorinostat 1012 0.48271
ARID1A | ASXL2 | d(CIITA) | Wnt-UP   ARID1A GDSC DLBC VX-11e 262 0.316
ARID1A | ASXL2 | d16q23.1   ARID1A GDSC DLBC VX-680 32 0.52592
¬MLL2 & ¬PTEN & ¬TLR-UP   d(CIITA) GDSC DLBC VX-702 1028 0.36506
¬ARID1A & CREBBP & ¬d15q15.1   CREBBP GDSC DLBC WH-4-023 56 0.26277
CREBBP & TP53 & ¬d15q15.1 & ¬IL-1-DOWN   MAPK_only-DOWN GDSC DLBC WZ-1-84 59 0.28589
JAK-STAT-UP   JAK-STAT-UP GDSC DLBC WZ3105 252 0.5
JAK-STAT-UP   JAK-STAT-UP GDSC PANCAN AR-42 272 0.42662
JAK-STAT-UP   JAK-STAT-UP GDSC PANCAN EX-527 341 0.50585
JAK-STAT-UP   JAK-STAT-UP GDSC PANCAN FR-180204 263 0.38748
JAK-STAT-UP   JAK-STAT-UP GDSC PANCAN Ruxolitinib 206 0.3996
ASXL2 | TP53 & MAPK_only-DOWN   ASXL2 GDSC DLBC XL-184 249 0.37433
¬TP53 & ¬TLR-UP & ¬Wnt-UP   MLL2 GDSC DLBC XMD13-2 330 0.29567
¬TP53 & ¬TLR-UP   ARID1A GDSC DLBC XMD14-99 253 0.29102
¬d(CIITA) & MAPK_only-DOWN & ¬PI3K_only-DOWN   MAPK_only-DOWN GDSC DLBC XMD8-85 106 0.54946
MLL2 & ¬MYC & ¬d(CDKN2A) & ¬MAPK_PI3K-DOWN   RNF43 GDSC DLBC YK_4-279 1239 0.47344
ASXL2 | MYC | MAPK_only-DOWN   MAPK_only-DOWN GDSC DLBC YM201636 310 0.3202
¬PTEN & TP53 & ¬d16q23.1   EP300 GDSC DLBC Zibotentan_ZD4054 266 0.38652
¬TP53 & ¬d16q23.1 & ¬d(CDKN2A) & ¬TLR-UP   MAPK_only-DOWN GDSC DLBC ZM-447439 1050 0.42159
NOTCH1 | a(KRAS) | a(ERBB2)   a(ERBB2) GDSC ESCA Afatinib 1032 0.32998
¬BAP1 & a(ERBB2) | NOTCH1 & ¬a(CCND1,CTTN)   a(EGFR) GDSC ESCA Afatinib__rescreen 1377 0.28697
NOTCH1 & ¬d20p12.1   NOTCH1 GDSC ESCA AICAR 1001 0.01457
Wnt-DOWN | NOTCH1 & ¬RB1   NOTCH1 GDSC ESCA AS601245 207 0.32021
¬RTN4 & ¬PIK3CA & ¬d2q22.1   NOTCH1 GDSC ESCA AZD-0530 38 0.19567
d20p12.1 & ¬a(EGFR) & ¬d(PAX5)   d20p12.1 GDSC ESCA BIRB_0796 1042 0.127
d20p12.1 | VEGF-DOWN   d20p12.1 GDSC ESCA BMS-345541 203 0.41607
d20p12.1 & ¬d16q23.1   d20p12.1 GDSC ESCA BMS-708163 1072 0.5
d2q22.1 & ¬Wnt-UP   d2q22.1 GDSC ESCA Cetuximab 1114 0.3361
¬SMAD2 & ¬a(FGFR1,WHSC1L1) & ¬d2q22.1 & a(ERBB2)   a(EGFR) GDSC ESCA CH5424802 281 0.42605
a(ERBB2) & ¬TGFB-DOWN   a(ERBB2) GDSC ESCA CP724714 255 0.16061
d20p12.1   d20p12.1 GDSC ESCA CX-5461 300 0.27789
¬BAP1 & a(CCND1,CTTN) & ¬ARID2 & ¬Wnt-UP   CREBBP GDSC ESCA Docetaxel 1007 0.40666
STK11 | SMAD4 | Wnt-DOWN   Wnt-DOWN GDSC ESCA EKB-569 282 0.23878
CREBBP & ¬RB1 | ¬a(ERBB2) & PI3K_only-UP   PI3K_only-UP GDSC ESCA Epothilone_B 201 0.50364
¬SMAD2 & ¬a(CCND1,CTTN) & ¬a(EGFR) & a(ERBB2)   d(PAX5) GDSC ESCA FR-180204 263 0.37169
a(EGFR)   a(EGFR) GDSC ESCA Gefitinib 1010 0.30349
a(CCND1,CTTN) & ¬a(EGFR) & ¬a(ERBB2) & ¬d16q23.1   RTN4 GDSC ESCA GSK-1904529A 202 0.43539
TLR-DOWN | Wnt-DOWN   d16q23.1 GDSC ESCA GSK2126458 283 0.50863
KDM6A | PI3K_only-UP   PI3K_only-UP GDSC ESCA GSK-650394 177 0.41342
d20p12.1 | Wnt-DOWN   d20p12.1 GDSC ESCA GSK690693 326 0.36777
MACF1 | FAT1 | TLR-DOWN | Wnt-DOWN   Wnt-DOWN GDSC ESCA KIN001-055 288 0.40103
¬a7q31.1 & ¬a(CCND1,CTTN) & ¬a(EGFR) & ¬PIK3CA   d20p12.1 GDSC ESCA KIN001-260 290 0.47895
MACF1   MACF1 GDSC ESCA MPS-1-IN-1 294 0.53042
¬CREBBP & a(EGFR) & ¬NFE2L2   BAP1 GDSC ESCA NSC-87877 147 0.35201
¬CDKN2A & PI3K_only-UP   PI3K_only-UP GDSC ESCA Obatoclax_Mesylate 182 0.50444
NOTCH1 | BAP1   NOTCH1 GDSC ESCA OSI-906 185 0.14757
d20p12.1 & ¬d(PAX5) | ¬a(KRAS) & VEGF-DOWN   VEGF-DOWN GDSC ESCA PD-0325901 1060 0.3361
ARID2 | KDM6A | NFE2L2   KDM6A GDSC ESCA PF-562271 158 0.23061
d20p12.1 | BAP1 | Wnt-DOWN   d16q23.1 GDSC ESCA QL-XI-92 329 0.23176
¬d2q22.1 & a(ERBB2)   a(ERBB2) GDSC ESCA rTRAIL 1261 0.18488
¬EP300 & ¬d(PAX5) & d2q22.1 & ¬d16q23.1   NCOR1 GDSC ESCA Tamoxifen 1199 0.16723
a(EGFR) | TGFB-DOWN   a(EGFR) GDSC ESCA Trametinib 1372 0.44164
¬RTN4 & ¬PIK3CA & ¬d2q22.1   ¬a(CCND1,CTTN) GDSC ESCA WZ-1-84 59 0.2484
a(CCND1,CTTN) & d2q22.1   TGFB-DOWN GDSC ESCA XAV_939 1268 0.38704
¬a(CCND1,CTTN) & d16q23.1   a7q31.1 GDSC ESCA XL-184 249 0.5112
¬a7q31.1 & d16q23.1   d16q23.1 GDSC ESCA XMD15-27 332 0.17613
d(PAX5) | KDM6A   d(PAX5) GDSC ESCA Y-39983 309 0.38327
¬BRAF & ¬PTEN   ¬PTEN GDSC GBM A-770041 55 0.24148
KDM6A | a(MDM2,NUP107) | d(ANK3),d10q22.1   a(MDM2,NUP107) GDSC GBM ABT-869 277 0.37126
d18p11.32 | a(FIP1L1,PDGFRA) | a(MDM2,NUP107) | d10p12.1   d10p12.1 GDSC GBM AMG-706 1029 0.31964
a(CDK4) | IL-1-UP   a(CDK4) GDSC GBM AP-24534 155 0.47792
KDM6A | a(FIP1L1,PDGFRA) | a(MDM2,NUP107)   a(AKAP9) GDSC GBM AV-951 312 0.4726
KDM6A | d17q21.2 | a(MYC) | d10q23.31   d17q21.2 GDSC GBM AZD6482 1066 0.49169
¬NF1 & d(CDKN2A) & ¬d(CDKN2C,FAF1) & ¬TGFB-UP   d3p14.1 GDSC GBM BIRB_0796 1042 0.47902
TP53 & ¬a7p14.3 & ¬H2O2-UP   d10p12.1 GDSC GBM Bleomycin__50_uM 1378 0.12538
¬BRAF & ¬a(CDK4) & ¬d(CDKN2C,FAF1) & ¬TGFB-UP   ¬d(CDKN2A) GDSC GBM Bortezomib 104 0.44176
PTEN & ¬d11q14.1 & ¬d10p12.1 & ¬H2O2-UP   RB1 GDSC GBM Bryostatin_1 197 0.22294
KDM6A | d17q21.2 | d8p21.3 | JAK-STAT-DOWN   JAK-STAT-DOWN GDSC GBM CCT007093 1067 0.4654
KDM6A   KDM6A GDSC GBM CHIR-99021 1241 0.53682
¬d(CDKN2C,FAF1) & ¬a7q11.23 & ¬TGFB-UP   NF1 GDSC GBM CX-5461 300 0.24796
¬RB1 & TP53 & ¬d(FAT1,IRF2) & ¬d(CDKN2C,FAF1)   a(AKAP9) GDSC GBM GSK269962A 1192 0.28276
¬RB1 & ¬d(CDKN2A)   d8p21.3 GDSC GBM GSK690693 326 0.3697
d(FAT1,IRF2) & VEGF-UP | d10p12.1 & ¬TGFB-UP   VEGF-UP GDSC GBM IOX2 1230 0.48259
d12q23.3 | d(TP53) | d10p12.1   d18p11.32 GDSC GBM JQ1 1218 0.48588
MAPK_only-UP   MAPK_only-UP GDSC GBM NSC-87877 147 0.58051
¬TP53 & ¬d(TP53) & ¬d(CDKN2C,FAF1) & ¬d3p14.1   a(EGFR) GDSC GBM Nutlin-3a 1047 0.12153
NF1 & ¬SACS | ¬d(CDKN2A) & ¬TGFB-UP   NF1 GDSC GBM Olaparib 1495 0.42994
a(AKAP9)   a(AKAP9) GDSC GBM Pazopanib 199 0.436
a(CDK4) | d8p21.3   d8p21.3 GDSC GBM PLX4720__rescreen 1371 0.42772
NF1   NF1 GDSC GBM QL-XI-92 329 0.35072
a(FIP1L1,PDGFRA) | d8p21.3 | IL-1-UP   IL-1-UP GDSC GBM RO-3306 1052 0.27804
¬EGFR & ¬NF1 & ¬MAPK_only-UP & ¬TGFB-UP   VEGF-UP GDSC GBM rTRAIL 1261 0.33754
¬RB1 & TP53 & ¬H2O2-UP   d(CDKN2C,FAF1) GDSC GBM SB_216763 1025 0.15342
d8p21.3   d8p21.3 GDSC GBM Tamoxifen 1199 0.5
¬d(CDKN2A) & ¬TGFB-UP   ¬d(CDKN2A) GDSC GBM Temozolomide 1375 0.457
d10q26.3 | a(EGFR) | H2O2-UP   H2O2-UP GDSC GBM TGX221 94 0.23932
¬PTEN & ¬TP53   d18p11.32 GDSC GBM Trametinib 1372 0.41265
¬a(EGFR) & ¬H2O2-UP & ¬MAPK_only-UP & ¬JAK-STAT-DOWN   NF1 GDSC GBM Tubastatin_A 265 0.37841
NF1 & ¬JAK-STAT-DOWN   NF1 GDSC GBM Y-39983 309 0.31718
a(CCND1,CTTN) & d(FAT1) & ¬TNFa-UP   a(NR2F2,PCSK6) GDSC HNSC 17-AAG 1026 0.55208
CASP8   CASP8 GDSC HNSC _5Z_-7-Oxozeaenol 1242 0.57672
a(ASXL1)   a(ASXL1) GDSC HNSC 681640 1046 0.40345
¬PIK3CA & ¬PTEN & ¬a(FANCG) & ¬dXq21.33   a(MCM3) GDSC HNSC ABT-888 1018 0.3723
¬d(CDKN2A) & d18q22.1 | a(EGFR)   a(EGFR) GDSC HNSC Afatinib 1032 0.38611
SMAD4 | a(EGFR) | Wnt-DOWN   a(EGFR) GDSC HNSC Afatinib__rescreen 1377 0.25651
¬PBRM1 & ¬d8p23.2 & ¬a22q11.21 & ¬a(CCND1,CTTN)   FBXW7 GDSC HNSC AKT_inhibitor_VIII 171 0.325
¬HLA-A & ¬a(CCND1,CTTN) & ¬dXq21.33 & ¬d(ATP1A1,CSDE1,NRAS)   Wnt-DOWN GDSC HNSC AZD6244 1498 0.33759
PIK3CA | a(FANCG)   a(FANCG) GDSC HNSC AZD6482 1066 0.36573
RASA1 | RHOA | SMAD4   SMAD4 GDSC HNSC Bicalutamide 1502 0.39657
FBXW7 | a(MYC),a8q24.21   BPTF GDSC HNSC BIRB_0796 1042 0.56494
SMAD4   SMAD4 GDSC HNSC Bleomycin__50_uM 1378 0.45235
SMAD4   SMAD4 GDSC PAAD BMS-708163 1072 0.48156
HLA-A | a6q11.1 | a(MDM2,NUP107,SRGAP1) | TNFa-UP   TNFa-UP GDSC HNSC BMS-708163 1072 0.50354
MYH9 | SMAD4 | a(ASXL1) | PI3K_only-UP   SMAD4 GDSC HNSC Bosutinib 1019 0.32682
a(ACTB,CARD11,PMS2,RAC1) | a(NR2F2,PCSK6)   CDKN2A GDSC HNSC CCT007093 1067 0.3524
HLA-A | PTEN | Wnt-DOWN   Wnt-DOWN GDSC HNSC Cetuximab 1114 0.35054
CDKN2A & ¬SPTAN1 | ¬d(CDKN2A) & Wnt-DOWN   a(ACTB,CARD11,PMS2,RAC1) GDSC HNSC CI-1040 1015 0.32849
MAPK_only-UP | MAPK_PI3K-UP | Wnt-DOWN   d(FAT1) GDSC HNSC CX-5461 300 0.42742
d8p23.2 & dXq21.33   SMAD4 GDSC HNSC Docetaxel 1007 0.57362
SMAD4 | a(FANCG) | MAPK_PI3K-UP   Wnt-DOWN GDSC HNSC EKB-569 282 0.36629
MYH9 & ¬TNFa-UP | d2q21.2 & ¬Wnt-DOWN   d2q21.2 GDSC HNSC Epothilone_B 201 0.47622
¬CASP8 & ¬NSD1 & ¬a(CCND1,CTTN) & ¬a3q28   d2q21.2 GDSC HNSC FTI-277 166 0.39927
SMAD4 | TNFa-UP   TNFa-UP GDSC HNSC GDC0941__rescreen 1527 0.15618
¬KDM6A & ¬NSD1 & TP53 & ¬a6q11.1   a(EGFR) GDSC HNSC Gefitinib 1010 0.24178
FBXW7 | MAPK_PI3K-UP | PI3K_only-DOWN   FBXW7 GDSC HNSC GSK-1904529A 202 0.34601
¬PIK3CA & d8p23.2 & ¬a(CCND1,CTTN)   SMAD4 GDSC HNSC GSK-650394 177 0.17198
Wnt-DOWN   Wnt-DOWN GDSC HNSC GSK690693 326 0.51487
Wnt-DOWN   Wnt-DOWN GDSC HNSC Shikonin 170 0.51144
Wnt-DOWN   Wnt-DOWN GDSC HNSC Trametinib 1372 0.29635
Wnt-DOWN   Wnt-DOWN GDSC SKCM HG-6-64-1 159 0.54632
FAT1 | FBXW7 | PBRM1 | a(ASXL1)   PI3K_only-UP GDSC HNSC GW_441756 1023 0.3638
CASP8 | PTEN | a(MYC),a8q24.21 | VEGF-DOWN   CDKN2A GDSC HNSC IOX2 1230 0.16364
RHOA   RHOA GDSC HNSC JNJ-26854165 1133 0.5
a(CCND1,CTTN) & d18q22.1 & ¬PI3K_only-UP   a(ASXL1) GDSC HNSC JNK_Inhibitor_VIII 1043 0.36966
FAT1   FAT1 GDSC HNSC JQ1 1218 0.26284
FAT1   FAT1 GDSC HNSC rTRAIL 1261 0.55024
VEGF-DOWN | Wnt-DOWN   Wnt-DOWN GDSC HNSC KIN001-055 288 0.40573
TP53 & ¬d(CDKN2A) & ¬dXq21.33   CDKN2A GDSC HNSC Lenalidomide 1020 0.44674
HLA-A | KDM6A | a(MYC),a8q24.21   a(ASXL1) GDSC HNSC NSC-87877 147 0.52591
KDM6A | MYH9 | SMAD4 | a22q11.21   a22q11.21 GDSC HNSC NVP-BEZ235 1057 0.27633
¬a(FANCG) & Wnt-DOWN | ¬d(MED17) & d2q21.2   MAPK_PI3K-UP GDSC HNSC Obatoclax_Mesylate 182 0.41324
¬d8p23.2 & ¬a(CCND1,CTTN) & ¬d18q22.1   Wnt-DOWN GDSC HNSC Olaparib 1495 0.40607
¬TNFa-UP & Wnt-DOWN | TP53 & PI3K_only-UP   PI3K_only-UP GDSC HNSC PD-0325901 1060 0.29195
BPTF | HLA-B | KDM6A   BPTF GDSC HNSC PD-173074 1049 0.5
KDM6A | PIK3CA | RHOA | VEGF-DOWN   FAT1 GDSC HNSC PF-562271 158 0.41726
TP53 & ¬a(FANCG) & ¬a(CCND1,CTTN) & ¬dXq21.33   HLA-A GDSC HNSC PFI-1 1219 0.3383
a(EGFR) & d(CDKN2A) | CASP8 & ¬d(ATP1A1,CSDE1,NRAS)   MAPK_PI3K-UP GDSC HNSC piperlongumine 1243 0.17363
d(CDKN2A) & MAPK_PI3K-UP | d(FAT1) & TNFa-UP   MAPK_PI3K-UP GDSC HNSC QL-XI-92 329 0.40224
APC | PTEN | SMAD4 | PI3K_only-UP   CASP8 GDSC HNSC RDEA119__rescreen 1526 0.43048
SMAD4 | PI3K_only-UP   SMAD4 GDSC HNSC RO-3306 1052 0.24848
¬a22q11.21 & ¬TNFa-UP & Wnt-DOWN   Wnt-DOWN GDSC HNSC SB590885 1061 0.48307
a(CCND1,CTTN) & d18q22.1   a(EGFR) GDSC HNSC SL_0101-1 1039 0.36902
PIK3CA & ¬d18q22.1 | ¬PIK3CA & SMAD4   CASP8 GDSC HNSC Tamoxifen 1199 0.40852
MYH9 | SMAD4   SMAD4 GDSC HNSC Vinblastine 1004 0.33514
¬a(EGFR) & Wnt-DOWN   EP300 GDSC HNSC Vinorelbine 140 0.19105
ATM | NSD1 | SMAD4 | a(MCM3)   a(MCM3) GDSC HNSC VX-702 1028 0.516
PBRM1 | a(ACTB,CARD11,PMS2,RAC1)   PBRM1 GDSC HNSC XAV_939 1268 0.32718
¬TP53 | MAPK_PI3K-UP   ¬TP53 GDSC HNSC Y-39983 309 0.23313
¬SOX9 & ¬VHL & d14q24.3   PI3K_only-DOWN GDSC KIRC ABT-263 1011 0.37272
NF2   NF2 GDSC KIRC Afatinib 1032 0.26438
NF2   NF2 GDSC KIRC Gefitinib 1010 0.23581
¬BAP1 & ¬TP53 & ¬VHL   NF2 GDSC KIRC Afatinib__rescreen 1377 0.14023
PBRM1 | TNFa-UP   PBRM1 GDSC KIRC AMG-706 1029 0.35707
¬TP53 & ¬MAPK_only-UP & ¬TNFa-UP   TGFB-DOWN GDSC KIRC AZD6482 1066 0.47387
¬SOX9 & ¬TP53 & d3p14.1 & ¬d1p31.1   PBRM1 GDSC KIRC BIRB_0796 1042 0.38369
¬VHL & d(CDKN2A) & ¬d(FAT1,IRF2) & ¬TNFa-UP   SMARCA4 GDSC KIRC Bleomycin__50_uM 1378 0.15162
KDM6A | MGA | PTEN   MGA GDSC KIRC CCT007093 1067 0.42271
¬BAP1 & ¬TP53 & ¬VHL & ¬d15q15.1   KDM6A GDSC KIRC Cetuximab 1114 0.29273
MGA | d3q11.1   d4q21.22 GDSC KIRC CH5424802 281 0.43067
¬TP53 & ¬VHL & ¬d(FAT1,IRF2) & ¬TNFa-UP   KDM6A GDSC KIRC CHIR-99021 1241 0.22335
PI3K_only-DOWN   PI3K_only-DOWN GDSC KIRC Cisplatin 1005 0.5
PI3K_only-DOWN   PI3K_only-DOWN GDSC SKCM QL-XI-92 329 0.30621
PTEN & TP53 | ¬TP53 & d3p14.1   d1p31.1 GDSC KIRC CX-5461 300 0.51822
NF2 | TGFB-DOWN   NF2 GDSC KIRC Dabrafenib 1373 0.10274
NF2 | TGFB-DOWN   NF2 GDSC KIRC Trametinib 1372 0.36125
¬BAP1 & NF2 & d(CDKN2A) & ¬d2q22.1   NF2 GDSC KIRC Gemcitabine 135 0.48489
¬d(SOX17) & d14q24.3 & ¬JAK-STAT-DOWN   d14q24.3 GDSC KIRC GSK429286A 230 0.13973
PTEN | d15q15.1 | TGFB-DOWN   PTEN GDSC KIRC GSK690693 326 0.23661
¬MGA & VHL & ¬MAPK_only-UP   PTEN GDSC KIRC JNJ-26854165 1133 0.16084
PBRM1 & VHL   PBRM1 GDSC KIRC JNK_Inhibitor_VIII 1043 0.28106
¬TP53 & d3p14.1 & ¬d2q22.1   d4q21.22 GDSC KIRC JW-7-24-1 256 0.39044
FBXW7 | ¬MGA & SETD2   SETD2 GDSC KIRC LFM-A13 192 0.49698
¬d6q27 & d(FAT1,IRF2) | d14q24.3 & MAPK_only-UP   MAPK_only-UP GDSC KIRC LY317615 229 0.53895
¬TP53 & d(FAT1,IRF2)   d(FAT1,IRF2) GDSC KIRC MP470 293 0.30879
¬TP53 & ¬d6q27 & ¬TGFB-DOWN   BAP1 GDSC KIRC Nutlin-3a 1047 0.19764
d4q21.22   d4q21.22 GDSC KIRC NVP-BEZ235 1057 0.50686
d3q11.1 & d(FAT1,IRF2) | ¬d6q27 & d14q24.3   d14q24.3 GDSC KIRC QL-XI-92 329 0.39629
EZH2   EZH2 GDSC KIRC rTRAIL 1261 0.50696
EZH2   EZH2 GDSC SKCM JQ12 164 0.51326
EZH2   EZH2 GDSC SKCM NVP-BHG712 295 0.50313
¬MGA & ¬d6q27 & d3p14.1 & ¬d2q22.1   d3q11.1 GDSC KIRC STF-62247 258 0.14796
¬BAP1 & ¬NF2 & ¬d1p31.1 & ¬MAPK_only-UP   d(SOX17) GDSC KIRC Temsirolimus 1016 0.43086
¬d8p23.1 & ¬MAPK_only-UP & ¬TNFa-UP & ¬VEGF-UP   d1p31.1 GDSC KIRC TGX221 94 0.32264
d2q22.1   d2q22.1 GDSC KIRC XAV_939 1268 0.5
¬NFE2L2 & ¬d(SOX17) & d14q24.3 & ¬d2q22.1   d14q24.3 GDSC KIRC Y-39983 309 0.37977
¬NOTCH1 & ¬TP53   TET2 GDSC LAML 5-Fluorouracil 179 0.14078
NPM1 | RUNX1-RUNX1T1 | U2AF1 | H2O2-DOWN   H2O2-DOWN GDSC LAML _5Z_-7-Oxozeaenol 1242 0.28138
¬ASXL1 & ¬NRAS & ¬IL-1-UP & JAK-STAT-UP   FBXW7 GDSC LAML A-770041 55 0.2563
d9p13.1 | ¬JAK-STAT-UP | H2O2-DOWN   ¬JAK-STAT-UP GDSC LAML ABT-263 1011 0.42186
¬NRAS & ¬IL-1-UP & ¬TLR-UP & ¬IL-1-DOWN   U2AF1 GDSC LAML ABT-869 277 0.26651
U2AF1 | d9p13.1 | VEGF-UP   d9p13.1 GDSC LAML ABT-888 1018 0.54912
¬KRAS & ¬NRAS   U2AF1 GDSC LAML AC220 254 0.034986
¬KRAS & ¬TP53 & ¬TLR-UP   U2AF1 GDSC LAML AICAR 1001 0.36636
FLT3 | MAP3K1 | RUNX1-RUNX1T1 | U2AF1   U2AF1 GDSC LAML AP-24534 155 0.38246
FLT3 | MAP3K1 | RUNX1-RUNX1T1 | U2AF1   U2AF1 GDSC LAML HG-6-64-1 159 0.30789
¬KRAS & ¬NOTCH1 & ¬NRAS & ¬d7p12.1   TLR-UP GDSC LAML AR-42 272 0.22627
KRAS | PML-RARA | TET2   TET2 GDSC LAML AS605240 224 0.40127
¬NRAS & TP53 & JAK-STAT-UP   U2AF1 GDSC LAML AT-7519 219 0.40162
NRAS & ¬TP53 | ¬RUNX1-RUNX1T1 & ASXL1   ASXL1 GDSC LAML ATRA 1009 0.16794
¬KRAS & ¬NRAS & ¬IL-1-UP & ¬TLR-UP   RUNX1-RUNX1T1 GDSC LAML AV-951 312 0.11824
¬TP53 & ¬TLR-UP   TET2 GDSC LAML AZ628 29 0.38809
¬EP300 & ¬TP53 & JAK-STAT-UP   NPM1 GDSC LAML AZD6244 1498 0.52353
U2AF1   U2AF1 GDSC LAML AZD7762 1022 0.40156
U2AF1   U2AF1 GDSC LAML Olaparib 1495 0.5
¬NF1 & ASXL1   ASXL1 GDSC LAML AZD8055 1059 0.39126
¬ASXL1 & ¬NOTCH1 & ¬NRAS & ¬TP53   FLT3 GDSC LAML BAY_61-3606 178 0.27554
CDKN2A | TET2 | IL-1-UP   TET2 GDSC LAML Bexarotene 186 0.04081
¬ASXL1 & ¬NRAS & JAK-STAT-UP & ¬H2O2-DOWN   SACS GDSC LAML Bicalutamide 1502 0.27351
¬CDKN2A & ¬TP53   PTPN11 GDSC LAML BIX02189 279 0.14999
ASXL1 | NOTCH1 | PML-RARA | TET2   ASXL1 GDSC LAML BMS-345541 203 0.30493
FLT3 | NOTCH1 | TET2 | IL-1-DOWN   H2O2-DOWN GDSC LAML BMS-509744 63 0.31112
¬NRAS & ¬JAK-STAT-UP & ¬TLR-UP   ASXL1 GDSC LAML BMS-536924 1091 0.39489
¬CREBBP & ¬KRAS & JAK-STAT-UP   SACS GDSC LAML BMS-708163 1072 0.22479
PML-RARA   PML-RARA GDSC LAML BMS-754807 184 0.5
PML-RARA   PML-RARA GDSC LAML SB590885 1061 0.5
¬ASXL1 & ¬NRAS & ¬IL-1-UP & JAK-STAT-UP   TET2 GDSC LAML Bryostatin_1 197 0.20673
FLT3 | U2AF1 | VEGF-UP   U2AF1 GDSC LAML BX-795 1037 0.22232
¬NRAS & ¬JAK-STAT-UP & ¬TNFa-UP   ASXL1 GDSC LAML BX-912 222 0.37755
¬CDKN2A & ¬DNMT3A & ¬TP53   ASXL1 GDSC LAML CAL-101 238 0.32081
¬CDKN2A & ¬DNMT3A & ¬TP53   ASXL1 GDSC LAML ZSTK474 223 0.32439
¬ASXL1 & ¬NOTCH1 & ¬NRAS & ¬H2O2-DOWN   PML-RARA GDSC LAML CAY10603 276 0.17107
¬CREBBP & ¬KRAS & ¬NRAS & TP53   STAG2 GDSC LAML CCT018159 1170 0.42492
FLT3 & H2O2-DOWN | ¬NRAS & TP53   FLT3 GDSC LAML CEP-701 1024 0.36011
¬MAP3K1 & ¬KRAS & ¬NRAS & ¬TLR-UP   FLT3 GDSC LAML CH5424802 281 0.53491
RUNX1-RUNX1T1 | SACS | VEGF-UP   SACS GDSC LAML CHIR-99021 1241 0.39835
¬d6p21.33 & ¬EP300 & ¬IL-1-UP & JAK-STAT-UP   KRAS GDSC LAML CI-1040 1015 0.27925
¬CREBBP & ¬NRAS & ¬TET2 & ¬d9p13.1   ASXL1 GDSC LAML CP466722 152 0.14021
¬ASXL1 & ¬EP300 & JAK-STAT-UP & ¬H2O2-DOWN   d6p21.33 GDSC LAML CP724714 255 0.43632
¬NRAS & ¬TP53 & ¬TLR-UP   FBXW7 GDSC LAML Crizotinib 37 0.37574
¬ASXL1 & ¬NRAS & JAK-STAT-UP   NOTCH1 GDSC LAML Cyclopamine 17 0.023908
FLT3 | PTPN11 | RUNX1-RUNX1T1 | U2AF1   RUNX1-RUNX1T1 GDSC LAML Dabrafenib 1373 0.48197
¬ASXL1 & ¬CREBBP & ¬NRAS   d6p21.33 GDSC LAML EKB-569 282 0.27517
¬NRAS & JAK-STAT-UP & ¬H2O2-DOWN & ¬IL-1-DOWN   TET2 GDSC LAML EX-527 341 0.14184
¬NRAS & JAK-STAT-UP   NOTCH1 GDSC LAML FMK 231 0.15741
¬FBXW7 & ¬NRAS & ¬d9p13.1 & ¬TLR-UP   TET2 GDSC LAML FR-180204 263 0.17739
RUNX1-RUNX1T1   RUNX1-RUNX1T1 GDSC LAML FTI-277 166 0.51844
RUNX1-RUNX1T1   RUNX1-RUNX1T1 GDSC LAML MP470 293 0.52232
RUNX1-RUNX1T1   RUNX1-RUNX1T1 GDSC LAML Nilotinib 1013 0.5
RUNX1-RUNX1T1   RUNX1-RUNX1T1 GDSC LAML Vorinostat 1012 0.5
CDKN2A   CDKN2A GDSC LAML GDC0941 1058 0.5
¬NF1 & ¬KRAS & ¬NRAS   TLR-UP GDSC LAML Genentech_Cpd_10 225 0.17031
¬TP53 | ¬NRAS & JAK-STAT-UP   ¬TP53 GDSC LAML GSK1070916 226 0.056544
¬NRAS & ¬JAK-STAT-UP   ASXL1 GDSC LAML GSK2126458 283 0.31162
RUNX1-RUNX1T1 | CREBBP   CREBBP GDSC LAML GSK269962A 1192 0.30488
¬TP53 & ¬U2AF1 & ¬MAPK_only-DOWN   PTPN11 GDSC LAML GSK429286A 230 0.21505
¬NOTCH1 & ¬NRAS & ¬TP53 & ¬TLR-UP   FLT3 GDSC LAML GSK-650394 177 0.19567
¬NRAS & ¬d9p13.1 & ¬JAK-STAT-UP   TLR-UP GDSC LAML GSK690693 326 0.39484
¬TP53 & ¬TLR-UP & ¬H2O2-DOWN   PTPN11 GDSC LAML GW-2580 193 0.23593
¬EP300 & ¬NRAS   ¬TP53 GDSC LAML I-BET_151 275 0.19528
IL-1-UP   IL-1-UP GDSC LAML JQ12 164 0.5
CREBBP | IL-1-UP | TLR-UP | H2O2-DOWN   TLR-UP GDSC LAML JQ1 1218 0.49299
¬NRAS & ¬U2AF1 & ¬d9p13.1 & ¬IL-1-DOWN   RUNX1-RUNX1T1 GDSC LAML JW-7-24-1 256 0.24224
TP53 & JAK-STAT-UP & ¬H2O2-DOWN & ¬IL-1-DOWN   d6p21.33 GDSC LAML KIN001-055 288 0.32655
ASXL1 & ¬d9p13.1 | ¬TP53 & ¬JAK-STAT-UP   ASXL1 GDSC LAML KIN001-102 228 0.2885
¬NRAS & ¬TP53 & JAK-STAT-UP   H2O2-DOWN GDSC LAML KIN001-135 91 0.053435
¬ASXL1 & ¬NRAS   TNFa-UP GDSC LAML KIN001-236 286 0.051102
¬MAP3K1 & ¬TP53 & JAK-STAT-UP   TET2 GDSC LAML KIN001-244 287 0.2603
¬KRAS & ¬NRAS & ¬U2AF1 & ¬TLR-UP   TET2 GDSC LAML KIN001-270 345 0.38799
d9p13.1 | VEGF-UP | H2O2-DOWN   VEGF-UP GDSC LAML KU-55933 1030 0.4772
¬KRAS & ¬NRAS & ¬SACS & ¬TLR-UP   IL-1-UP GDSC LAML LAQ824 200 0.36483
¬TP53 & JAK-STAT-UP | STAG2 & ¬KRAS   STAG2 GDSC LAML Lenalidomide 1020 0.42962
SACS & ¬IL-1-DOWN   FBXW7 GDSC LAML LY317615 229 0.50545
¬NRAS & ¬JAK-STAT-UP   RUNX1-RUNX1T1 GDSC LAML Masitinib 292 0.18754
JAK-STAT-UP & ¬IL-1-DOWN   U2AF1 GDSC LAML Methotrexate 1008 0.18024
FLT3 | PTPN11 | RUNX1-RUNX1T1 | U2AF1   U2AF1 GDSC LAML Midostaurin 153 0.30717
TET2 & ¬H2O2-DOWN | CREBBP & NOTCH1   TET2 GDSC LAML MPS-1-IN-1 294 0.28454
¬CREBBP & ¬KRAS & ¬NRAS & ¬MAPK_only-DOWN   U2AF1 GDSC LAML NG-25 260 0.10205
¬CREBBP & ¬KRAS & ¬NRAS & ¬MAPK_only-DOWN   U2AF1 GDSC LAML TL-1-85 261 0.11672
¬ASXL1 & ¬NRAS & ¬SACS & ¬IL-1-UP   PML-RARA GDSC LAML NPK76-II-72-1 257 0.33712
FLT3 | PTPN11 | TET2   PTPN11 GDSC LAML NVP-TAE684 35 0.45384
¬NRAS & ¬JAK-STAT-UP   ¬JAK-STAT-UP GDSC LAML OSI-027 299 0.19806
¬NRAS & ¬JAK-STAT-UP   ¬JAK-STAT-UP GDSC LAML PI-103 302 0.29938
KRAS   KRAS GDSC LAML OSI-906 185 0.51936
¬CREBBP & ¬KRAS & ¬NRAS & ¬TLR-UP   d7p12.1 GDSC LAML OSI-930 298 0.23964
¬ASXL1 & ¬NRAS & JAK-STAT-UP & ¬H2O2-DOWN   TET2 GDSC LAML PAC-1 175 0.38637
¬SACS & ¬U2AF1 & ¬IL-1-UP & JAK-STAT-UP   NRAS GDSC LAML PD-0325901 1060 0.34759
TP53 & ¬JAK-STAT-UP | ¬CREBBP & EP300   VEGF-UP GDSC LAML PD-173074 1049 0.47022
¬FBXW7 & ¬KRAS & ¬NRAS & JAK-STAT-UP   FLT3 GDSC LAML PF-562271 158 0.088849
¬NRAS & ¬SACS & TP53 & ¬IL-1-DOWN   RUNX1-RUNX1T1 GDSC LAML PFI-1 1219 0.44872
¬CREBBP & ¬NRAS & ¬TP53 & ¬TLR-UP   PTPN11 GDSC LAML PHA-665752 6 0.21457
FLT3 | PML-RARA | TET2 | U2AF1   PML-RARA GDSC LAML PHA-793887 301 0.43191
PTPN11 | CREBBP | SACS | IL-1-UP   CREBBP GDSC LAML Phenformin 196 0.39019
ASXL1 | ¬TP53   ¬TP53 GDSC LAML PIK-93 303 0.095277
TET2   TET2 GDSC LAML PXD101_Belinostat 274 0.48851
TET2   TET2 GDSC PANCAN Bexarotene 186 0.46581
¬NRAS & ¬JAK-STAT-UP   TNFa-UP GDSC LAML QL-X-138 331 0.39591
RUNX1-RUNX1T1 | PML-RARA | ¬TP53   ¬TP53 GDSC LAML QL-XI-92 329 0.17604
¬d6p21.33 & ¬SACS & ¬IL-1-UP & JAK-STAT-UP   NRAS GDSC LAML RDEA119 1014 0.46013
¬NOTCH1 & ¬NRAS & ¬IL-1-UP & JAK-STAT-UP   d9p13.1 GDSC LAML RDEA119__rescreen 1526 0.44796
¬JAK-STAT-UP & H2O2-DOWN | KRAS & ¬NRAS   KRAS GDSC LAML rTRAIL 1261 0.3264
¬KRAS & ¬NRAS & ¬U2AF1 & ¬TLR-UP   SACS GDSC LAML Ruxolitinib 206 0.14916
¬PTPN11 & ¬NRAS & ¬JAK-STAT-UP & ¬TLR-UP   U2AF1 GDSC LAML SGC0946 1264 0.35382
¬ASXL1 & ¬NRAS & ¬SACS   U2AF1 GDSC LAML SNX-2112 328 0.19083
FLT3 | U2AF1   U2AF1 GDSC LAML Sorafenib 30 0.28521
¬CDKN2A & ¬d9p13.1 & JAK-STAT-UP   H2O2-DOWN GDSC LAML STF-62247 258 0.2934
¬NOTCH1 & ¬NRAS & ¬TP53 & ¬TLR-UP   U2AF1 GDSC LAML Sunitinib 5 0.38389
¬NOTCH1 & ¬NRAS & ¬TP53 & ¬TLR-UP   U2AF1 GDSC LAML XL-880 308 0.35272
MAP3K1 | d6p21.33   d6p21.33 GDSC LAML TAK-715 221 0.53954
¬NRAS & JAK-STAT-UP & ¬H2O2-DOWN   d9p13.1 GDSC LAML Tamoxifen 1199 0.19308
¬PTPN11 & ¬ASXL1 & ¬NRAS & ¬H2O2-DOWN   U2AF1 GDSC LAML Temozolomide 1375 0.31439
¬NRAS   ¬NRAS GDSC LAML TG101348 306 0.0015423
¬NRAS & ¬d9p13.1 & JAK-STAT-UP   U2AF1 GDSC LAML THZ-2-102-1 346 0.23595
U2AF1 & ¬JAK-STAT-UP | TET2 & JAK-STAT-UP   TET2 GDSC LAML THZ-2-49 344 0.5279
¬FLT3 & ¬ASXL1 & ¬NRAS & ¬SACS   TLR-UP GDSC LAML Tipifarnib 204 0.42636
¬CDKN2A & ¬TP53 & ¬TLR-UP   PTPN11 GDSC LAML TL-2-105 211 0.19702
¬NOTCH1 & ¬NRAS & ¬MAPK_only-DOWN   IL-1-UP GDSC LAML TPCA-1 305 0.0097261
NPM1 | H2O2-DOWN   H2O2-DOWN GDSC LAML Trametinib 1372 0.47917
RUNX1-RUNX1T1 | SACS   RUNX1-RUNX1T1 GDSC LAML UNC1215 1262 0.47342
KRAS | TET2   TET2 GDSC LAML VNLG124 271 0.32969
¬SACS & ¬TP53 & JAK-STAT-UP   TET2 GDSC LAML VX-11e 262 0.36667
¬NPM1 & ¬TP53   TLR-UP GDSC LAML VX-680 32 0.18833
¬NRAS & TP53 & ¬IL-1-DOWN   STAG2 GDSC LAML VX-702 1028 0.45404
FLT3 | PML-RARA | TET2 | U2AF1   FLT3 GDSC LAML WZ3105 252 0.35731
FLT3 | PTPN11 | TET2 | U2AF1   U2AF1 GDSC LAML XL-184 249 0.31607
PTPN11 | NOTCH1 | PML-RARA | TLR-UP   PML-RARA GDSC LAML XMD13-2 330 0.44709
d6p21.33 & NRAS | ¬KRAS & ¬NRAS   ¬TP53 GDSC LAML XMD14-99 253 0.14714
¬ASXL1 & ¬CREBBP & ¬NRAS   TLR-UP GDSC LAML XMD15-27 332 0.037572
CDKN2A | ¬NRAS   ¬NRAS GDSC LAML Y-39983 309 0.023136
¬TP53 & ¬JAK-STAT-UP   TET2 GDSC LAML YM201636 310 0.099833
¬TP53 & JAK-STAT-UP | SACS & ¬U2AF1   CREBBP GDSC LAML Zibotentan_ZD4054 266 0.31353
FLT3 | STAG2 | ASXL1 | EP300   FLT3 GDSC LAML ZM-447439 1050 0.28916
¬EP300 & ¬d(RPL22) & ¬PI3K_only-DOWN   a(KRAS) GDSC LGG A-770041 55 0.37454
¬TP53 & H2O2-UP | ¬PTEN & a(EGFR)   a(EGFR) GDSC LGG Bleomycin__50_uM 1378 0.29229
¬PTEN & H2O2-UP | a(EGFR) & ¬TNFa-UP   a(EGFR) GDSC LGG Docetaxel 1007 0.26225
¬EP300 & ¬d(RPL22) & ¬a(FGFR1,WHSC1L1) & ¬d(CUL2)   SMARCA4 GDSC LGG GSK690693 326 0.49308
¬SMARCA4 & ¬TP53   ¬TP53 GDSC LGG Nutlin-3a 1047 0.052348
EP300 | SETD2 | IL-1-UP | PI3K_only-DOWN   IL-1-UP GDSC LGG QL-XI-92 329 0.28445
¬EP300 & ¬d(RPL22) & ¬TGFB-UP   a(EGFR) GDSC LGG RO-3306 1052 0.13528
H2O2-UP | PI3K_only-DOWN   H2O2-UP GDSC LGG SB_216763 1025 0.029282
¬PTEN & a(EGFR)   a(EGFR) GDSC LGG Tubastatin_A 265 0.20132
¬d(CUL2) & TGFB-UP & ¬TNFa-UP & ¬PI3K_only-DOWN   TLR-DOWN GDSC LGG Y-39983 309 0.26507
¬PHLPP1 & ¬d(CDKN2A) & ¬IL-1-UP & ¬MAPK_only-DOWN   ¬TP53 GDSC LIHC CX-5461 300 0.35542
ACVR2A | PHLPP1 | RB1 | CTNNB1   FAM123B GDSC LIHC FH535 173 0.5
ACVR2A | CREBBP | CTNNB1 | d(RB1)   d(RB1) GDSC LIHC GSK-1904529A 202 0.38961
¬TP53 & ¬CREBBP | ¬RB1 & IL-1-UP   IL-1-UP GDSC LIHC JQ1 1218 0.54794
MAPK_PI3K-UP   MAPK_PI3K-UP GDSC LIHC NSC-207895 269 0.5
MAPK_PI3K-UP   MAPK_PI3K-UP GDSC PAAD FMK 231 0.54736
ACVR2A | CREBBP | CTNNB1 | d(RB1)   ¬TP53 GDSC LIHC Pazopanib 199 0.42007
CTNNB1 | SMARCA4 | d(RB1)   ¬TP53 GDSC LIHC Tipifarnib 204 0.33807
¬TP53 & ¬CTNNB1 | FAM123B & ¬CTNNB1   ¬TP53 GDSC LIHC Trametinib 1372 0.22387
TP53 & ¬d(CDKN2A) & ¬FAM123B & ¬MAPK_PI3K-UP   ARID1A GDSC LIHC Y-39983 309 0.44821
CUL2 | a(ARFGAP1)   CUL2 GDSC LUAD 17-AAG 1026 0.46261
¬SMARCA4 & a(CCND1) | a(MET) & ¬d(FAT1,IRF2)   EGFR GDSC LUAD A-770041 55 0.38428
EGFR   EGFR GDSC LUAD Afatinib 1032 0.20778
EGFR   EGFR GDSC LUAD EKB-569 282 0.22065
EGFR | d22q13.31   EGFR GDSC LUAD Afatinib__rescreen 1377 0.18778
d(CDKN2A) & a(TERT) | ¬SMARCA4 & SVEP1   a(TERT) GDSC LUAD AKT_inhibitor_VIII 171 0.46987
¬TP53 & ¬MAPK_only-UP & ¬JAK-STAT-DOWN   TGFB-DOWN GDSC LUAD AMG-706 1029 0.41633
KEAP1 | PI3K_only-UP | TGFB-DOWN   PI3K_only-UP GDSC LUAD AS601245 207 0.39907
d17p11.2 | a(MECOM)   d17p11.2 GDSC LUAD AS605240 224 0.23892
¬STK11 & a(ARFGAP1) | U2AF1 & MAPK_only-UP   a(TERT) GDSC LUAD AUY922 194 0.22683
SOX9 | a(ARFGAP1) | PI3K_only-UP   PI3K_only-UP GDSC LUAD Bicalutamide 1502 0.36596
CDKN2A | MAP4K3 | NTRK2 | d17p11.2   CDKN2A GDSC LUAD BIRB_0796 1042 0.38741
KRAS & ¬RBM10 & ¬d19p12 & ¬a12q12   a(CCND1) GDSC LUAD Bleomycin__50_uM 1378 0.41683
d22q11.1 & ¬d22q13.31 | a(KRAS) & ¬a12q12   a(KRAS) GDSC LUAD Bleomycin 190 0.25487
d(SMARCA4)   d(SMARCA4) GDSC LUAD BMS-345541 203 0.43334
d(SMARCA4)   d(SMARCA4) GDSC LUAD Ruxolitinib 206 0.31704
U2AF1 | a(FOXA2)   U2AF1 GDSC LUAD BMS-536924 1091 0.29182
d22q11.1 & ¬aXq28 | KRAS & a(MYC)   d22q11.1 GDSC LUAD BMS-708163 1072 0.41887
KRAS & ¬RBM10 & ¬SMARCA4   KEAP1 GDSC LUAD BMS-754807 184 0.35835
¬NRAS & ¬a(ASXL1) & a(MYC) & ¬a(CCND1)   a(TERT) GDSC LUAD Bryostatin_1 197 0.37369
d17p11.2   d17p11.2 GDSC LUAD CCT007093 1067 0.23475
d17p11.2   d17p11.2 GDSC LUAD Midostaurin 153 0.41156
STK11 & d(CDKN2A) | d(CDKN2A) & a(CCND1)   a(CCND1) GDSC LUAD CCT018159 1170 0.49924
BRAF | EGFR | d(SMARCA4) | a(EGFR)   a(EGFR) GDSC LUAD Cetuximab 1114 0.32741
¬SMARCA4 & TP53 & d(CDKN2A) & ¬d(FAT1,IRF2)   a(TERT) GDSC LUAD CH5424802 281 0.42819
BRAF | PI3K_only-UP | PI3K_only-DOWN | TGFB-DOWN   PI3K_only-UP GDSC LUAD CHIR-99021 1241 0.50197
d(TFDP1) & d(FAT1,IRF2) | ¬KRAS & STK11   a(MECOM) GDSC LUAD CP724714 255 0.37132
KRAS & ¬a(MET) & ¬d(TFDP1) & ¬MAPK_PI3K-UP   a(TERT) GDSC LUAD CX-5461 300 0.43812
¬SMARCA4 & ¬a(FOXA2) & ¬d(FAT1,IRF2)   d(TFDP1) GDSC LUAD Dasatinib 51 0.10537
d(CDKN2A) & a(MYC)   RBM10 GDSC LUAD DMOG 165 0.49344
¬SMARCA4 & d(CDKN2A) & a(MYC)   d18p11.21 GDSC LUAD Epothilone_B 201 0.095226
¬CTNNB1 & ¬KRAS & ¬NF1 & ¬a(ARFGAP1)   d(TFDP1) GDSC LUAD Erlotinib 1 0.54242
EGFR & ¬a(CCND1)   EGFR GDSC LUAD FR-180204 263 0.11469
EGFR & ¬a(CCND1)   EGFR GDSC LUAD Gefitinib 1010 0.13665
a(ARFGAP1) | PI3K_only-UP | PI3K_only-DOWN   a(CCND1) GDSC LUAD FTI-277 166 0.301
TP53 & MAPK_only-UP   MAPK_only-UP GDSC LUAD Gemcitabine 135 0.51783
a(MET) & a(MYC) | RBM10 & d19p12   a(MET) GDSC LUAD GSK-1904529A 202 0.46237
¬STK11 & ¬a(CDK4) & a(MYC)   a(ARFGAP1) GDSC LUAD GSK269962A 1192 0.53802
SVEP1   SVEP1 GDSC LUAD GSK-650394 177 0.38744
EGFR | HLA-A | U2AF1 | d22q13.31   d22q13.31 GDSC LUAD GSK690693 326 0.25676
ARID1A | d(SMARCA4) | PI3K_only-UP | Wnt-UP   ARID1A GDSC LUAD GW_441756 1023 0.44346
EGFR | KEAP1 | U2AF1 | d22q11.1   d22q11.1 GDSC LUAD HG-5-88-01 1143 0.43538
CLASP2 | d(SMARCA4)   d(SMARCA4) GDSC LUAD IOX2 1230 0.34477
KRAS & ¬MAPK_PI3K-UP   POLR2B GDSC LUAD JNK_Inhibitor_VIII 1043 0.22169
¬a(CDK4) & ¬a(ASXL1) & a(MYC)   d18p11.21 GDSC LUAD JQ12 164 0.4999
EGFR | MAP4K3 | d22q13.31 | Wnt-DOWN   EGFR GDSC LUAD KIN001-055 288 0.31842
¬KRAS & STK11 & ¬d22q11.1 & ¬a(FOXA2)   STK11 GDSC LUAD KIN001-102 228 0.41465
d(CDKN2A) & ¬d22q11.1 & ¬a(MYC) & ¬d(FAT1,IRF2)   a(TERT) GDSC LUAD KIN001-260 290 0.48481
CUL2   CUL2 GDSC LUAD KU-55933 1030 0.5
¬BRAF & ¬d(PAX5) & d17p11.2 & ¬a(CDK4)   d17p11.2 GDSC LUAD LAQ824 200 0.51358
DDX3X | MAP4K3 | STK11 | d(SMARCA4)   d(SMARCA4) GDSC LUAD LY317615 229 0.51813
¬SMARCA4 & d(CDKN2A) & ¬d13q14.2 & ¬d(FAT1,IRF2)   a(KRAS) GDSC LUAD Mitomycin_C 136 0.26032
KEAP1   KEAP1 GDSC LUAD OSI-906 185 0.51769
d18p11.21   d18p11.21 GDSC LUAD OSU-03012 167 0.5042
¬CLASP2 & KRAS & ¬d22q11.1   ¬TP53 GDSC LUAD PD-0325901 1060 0.20651
¬SMARCA4 & ¬d(PAX5) & d(FAT1,IRF2)   NF1 GDSC LUAD PF-4708671 1129 0.48802
STK11 & ¬a(ARFGAP1)   STK11 GDSC LUAD QL-XI-92 329 0.31578
KRAS & d(TFDP1) | STK11 & ¬a(MYC)   RBM10 GDSC LUAD RDEA119__rescreen 1526 0.30498
KRAS & d(CDKN2A) | CTNNB1 & ¬PI3K_only-UP   CDKN2A GDSC LUAD RO-3306 1052 0.44289
STK11   STK11 GDSC LUAD rTRAIL 1261 0.45062
¬BRAF & a(FOXA2) & ¬d(FAT1,IRF2)   a(FOXA2) GDSC LUAD SB_216763 1025 0.53765
¬STK11 & ¬TP53 & ¬a(EGFR) & ¬JAK-STAT-DOWN   d17p11.2 GDSC LUAD SB52334 304 0.45547
d22q11.1 & d22q13.31   d22q13.31 GDSC LUAD STF-62247 258 0.51466
¬SMARCA4 & SVEP1   SVEP1 GDSC LUAD Thapsigargin 180 0.51946
STK11 & PI3K_only-UP | a(TERT) & ¬a(EGFR)   a(TERT) GDSC LUAD Tipifarnib 204 0.54767
d(SMARCA4) | a(FUS,TAOK2) | a(MECOM) | VEGF-UP   d(SMARCA4) GDSC LUAD TL-2-105 211 0.35519
¬CTNNB1 & KRAS & ¬d19p12 & ¬a(ASXL1)   KRAS GDSC LUAD Trametinib 1372 0.16357
¬a(KRAS) & ¬a(CDK4) & ¬a(ASXL1) & a(MYC)   TGFB-DOWN GDSC LUAD Tubastatin_A 265 0.51211
d18p11.21 | a(ARFGAP1) | PI3K_only-DOWN | TNFa-DOWN   d17p11.2 GDSC LUAD Vinorelbine 140 0.49953
d17p11.2 & ¬d(FAT1,IRF2)   d17p11.2 GDSC LUAD VX-11e 262 0.49732
¬STK11 & ¬d(FAT1,IRF2)   d18p11.21 GDSC LUAD WH-4-023 56 0.12424
SVEP1 | d(TFDP1)   SVEP1 GDSC LUAD XAV_939 1268 0.50933
¬KRAS & ¬SMARCA4 & ¬a(MYC) & ¬d(FAT1,IRF2)   BRAF GDSC LUAD XMD14-99 253 0.10577
d(SMARCA4) | d17p11.2 | a(CCND1)   d17p11.2 GDSC LUAD Y-39983 309 0.36163
¬HRAS & ¬a(CCT5,TERT,TRIO) & ¬d13q13.1   PIK3CA GDSC LUSC Afatinib 1032 0.19904
¬d(CDKN2A)   ¬d(CDKN2A) GDSC LUSC CX-5461 300 0.088171
d18q21.2   d18q21.2 GDSC LUSC rTRAIL 1261 0.32283
¬PBRM1 & ¬PIK3CA & ¬a3q26.1 & ¬PI3K_only-UP   d(SMARCA4) GDSC LUSC Trametinib 1372 0.18793
¬d(CDKN2A) | ¬a3q26.1 & MAPK_only-UP   ¬d(CDKN2A) GDSC LUSC Y-39983 309 0.14827
ARID1A & ¬TP53 | ¬dXp22.32 & d8p21.3   ARID1B GDSC OV ABT-263 1011 0.19342
¬FBXW7 & ¬KRAS & ¬a19q12 & ¬d18q22.1   PIK3CA GDSC OV Afatinib 1032 0.30225
ARID2 | CTNNB1 | TGFB-DOWN   CTNNB1 GDSC OV Afatinib__rescreen 1377 0.32093
d15q25.2   d15q25.2 GDSC OV AMG-706 1029 0.31661
EP300 | MLL2 | VEGF-UP   BRAF GDSC OV Bleomycin__50_uM 1378 0.414
a(MYC)   a(MYC) GDSC OV Cetuximab 1114 0.39853
a(MYC)   a(MYC) GDSC STAD QL-XI-92 329 0.45192
EP300 | d19q13.32 | d15q25.2 | TGFB-DOWN   dXq22.3 GDSC OV Elesclomol 1031 0.29931
¬KRAS & ¬a(CCNE1) & ¬dXp22.32 & ¬d(ARID1B,MAP3K4,MLLT4)   PIK3CA GDSC OV Gefitinib 1010 0.24547
dXq22.3   dXq22.3 GDSC OV GW_441756 1023 0.23277
BRAF | CTNNB1 | Wnt-DOWN   CTNNB1 GDSC OV IOX2 1230 0.27448
ARID1A & ¬PIK3CA | a(SOX17) & ¬a3q27.1   PIK3R1 GDSC OV JNK_Inhibitor_VIII 1043 0.4741
¬SMARCA4 & TP53 & ¬a(KRAS) & ¬d8p21.3   d16q23.2 GDSC OV KIN001-260 290 0.3175
KRAS | a(TRIO) | MAPK_only-UP | JAK-STAT-DOWN   d18q21.2 GDSC OV PD-0325901 1060 0.41049
KRAS & ¬TP53 | ¬SMAD4 & d(ARID1B,MAP3K4,MLLT4)   PTEN GDSC OV QL-XII-61 1203 0.48948
¬TP53 & ¬d(ARID1B,MAP3K4,MLLT4) | d16q23.3 & ¬dXp21.1   d16q23.3 GDSC OV SB590885 1061 0.53525
KRAS | d21q22.3 | MAPK_only-UP | PI3K_only-UP   d18q21.2 GDSC OV Trametinib 1372 0.32147
¬KRAS & ¬a(KRAS) & ¬dXp21.1 & ¬d(ARID1B,MAP3K4,MLLT4)   a(MDM2,NUP107) GDSC OV Tubastatin_A 265 0.42515
a(SOX17) | PI3K_only-UP | JAK-STAT-DOWN   a(SOX17) GDSC OV XAV_939 1268 0.29728
BRAF | EP300 | FBXW7 | SMARCA4   KRAS GDSC OV Y-39983 309 0.46626
¬SMAD4 & a(KRAS) & ¬MAPK_PI3K-UP & ¬TLR-DOWN   EP300 GDSC PAAD AS605240 224 0.48675
¬RNF43 & ¬d(CDKN2A) & ¬MAPK_PI3K-UP   a(WNK1) GDSC PAAD AZD6244 1498 0.42145
¬ARID1A & TLR-DOWN   TLR-DOWN GDSC PAAD BIRB_0796 1042 0.5
RNF43 | VEGF-DOWN   RNF43 GDSC PAAD BMS-536924 1091 0.081107
SACS | TLR-UP | TLR-DOWN | Wnt-DOWN   TLR-UP GDSC PAAD BMS-754807 184 0.52296
TLR-DOWN   TLR-DOWN GDSC PAAD CI-1040 1015 0.5
CDKN2A & ¬VEGF-UP   EP300 GDSC PAAD CX-5461 300 0.38988
¬PBRM1 & RNF43 | EP300 & a(KRAS)   Wnt-DOWN GDSC PAAD Dabrafenib 1373 0.21972
KRAS & ¬SMAD4 & ¬a(KRAS) & ¬TGFB-DOWN   TLR-DOWN GDSC PAAD FH535 173 0.36891
CDKN2A | a18q11.1   CDKN2A GDSC PAAD GW-2580 193 0.54911
¬SMAD4 & ¬a(KRAS) & d(CDKN2A)   ¬KRAS GDSC PAAD JQ1 1218 0.35581
SMAD4 & ¬Wnt-DOWN   TLR-UP GDSC PAAD OSI-906 185 0.50335
KRAS & ¬a(KRAS) & ¬PI3K_only-UP & ¬TGFB-DOWN   ARID1A GDSC PAAD PD-0325901 1060 0.16545
MAPK_PI3K-UP | VEGF-DOWN   MAPK_PI3K-UP GDSC PAAD QL-XI-92 329 0.50793
¬MAP2K4 & TP53 & ¬a(KRAS) & ¬TGFB-DOWN   VEGF-DOWN GDSC PAAD RDEA119 1014 0.46835
EP300 & a(KRAS)   EP300 GDSC PAAD RDEA119__rescreen 1526 0.53462
¬ARID1A & ¬FBXW7 & ¬a18q11.1 & d(CDKN2A)   EP300 GDSC PAAD rTRAIL 1261 0.17391
¬d(CDKN2A) & ¬MAPK_PI3K-UP & ¬VEGF-UP   RNF43 GDSC PAAD Trametinib 1372 0.35099
CDKN2A & ¬SMAD4 & ¬VEGF-UP   CDKN2A GDSC PAAD Tubastatin_A 265 0.48292
ARID1A | EP300 | RNF43   CDKN2A GDSC PAAD VX-11e 262 0.45925
SACS | Wnt-DOWN   PI3K_only-UP GDSC PAAD XAV_939 1268 0.42888
EP300 & a(KRAS) | CDKN2A & TP53   EP300 GDSC PAAD Y-39983 309 0.50187
d19q13.43 | JAK-STAT-UP | TLR-UP   JAK-STAT-UP GDSC PANCAN 5-Fluorouracil 179 0.37913
BRAF | CDKN1B | NRAS | JAK-STAT-UP   BRAF GDSC PANCAN _5Z_-7-Oxozeaenol 1242 0.21784
d(FGFR3),d4p16.3   d(FGFR3),d4p16.3 GDSC PANCAN 681640 1046 0.4943
MLL2 | PIK3CA | d21q11.2   MLL2 GDSC PANCAN A-443654 86 0.4868
BCR-ABL | CREBBP | NF2 | NOTCH1   d(APC) GDSC PANCAN A-770041 55 0.4836
d(CHD3,GPS2,TP53) | JAK-STAT-UP | TLR-UP | TNFa-DOWN   TNFa-DOWN GDSC PANCAN ABT-263 1011 0.34059
CDKN1B | FLT3 | d12p12.3   JAK-STAT-UP GDSC PANCAN ABT-869 277 0.42319
EP300 | a9p24.1 | JAK-STAT-UP | TLR-UP   EP300 GDSC PANCAN ABT-888 1018 0.47143
d(CREBBP) | d12p12.3 | H2O2-DOWN | MAPK_only-DOWN   JAK-STAT-UP GDSC PANCAN AC220 254 0.44184
a(EGFR) | a(CDK12,ERBB2,MED24)   a(CDK12,ERBB2,MED24) GDSC PANCAN Afatinib 1032 0.33737
d8p23.1 | a(CDK12,ERBB2,MED24) | Wnt-DOWN   a(CDK12,ERBB2,MED24) GDSC PANCAN Afatinib__rescreen 1377 0.374
EWSR1-FLI1 | d16p13.3 | TLR-DOWN   EWSR1-FLI1 GDSC PANCAN AG-014699 1175 0.43722
NOTCH1 | d(SDHD) | d(GNAQ,NTRK2,PCSK5,TJP2) | JAK-STAT-UP   JAK-STAT-UP GDSC PANCAN AICAR 1001 0.46196
FGFR2 | PIK3CA | a(EGFR)   PIK3CA GDSC PANCAN AKT_inhibitor_VIII 171 0.4022
¬a(EGFR) & d(BNC2,CDKN2A,JAK2,PSIP1) & ¬d(SRGAP3) & dXp11.3   TGFB-UP GDSC PANCAN AMG-706 1029 0.39296
¬d3p14.2 & dXq22.3   JAK-STAT-UP GDSC PANCAN AP-24534 155 0.32352
CTNND1 | a(CLTC,PPM1D) | d21q11.2   d21q11.2 GDSC PANCAN AS601245 207 0.42618
BRAF | NRAS | JAK-STAT-UP   NRAS GDSC PANCAN AS605240 224 0.2601
a(INPP4A) | JAK-STAT-UP | MAPK_only-DOWN   JAK-STAT-UP GDSC PANCAN AT-7519 219 0.38912
¬d3p14.2 & dXq21.33   JAK-STAT-UP GDSC PANCAN ATRA 1009 0.39283
¬d(ARID1B,MAP3K4,MLLT4) & dXp11.3 & ¬d(ERCC3) & ¬d20p12.1   a(ARFGAP1,GNAS) GDSC PANCAN AUY922 194 0.48074
¬d3p14.2 & dXq28   ASXL1 GDSC PANCAN AV-951 312 0.39864
ASXL1 | BCR-ABL | SMARCA4 | IL-1-DOWN   BCR-ABL GDSC PANCAN Axitinib 1021 0.36098
BRAF | KRAS | NRAS | JAK-STAT-UP   BRAF GDSC PANCAN AZ628 29 0.25172
BCR-ABL | NOTCH1   NOTCH1 GDSC PANCAN AZD-0530 38 0.34692
BRAF | KRAS | NRAS | PML-RARA   BRAF GDSC PANCAN AZD6244 1498 0.21964
¬d(BNC2,CDKN2A,JAK2,PSIP1) & ¬d3p14.2 & ¬dXp21.1   VHL GDSC PANCAN AZD6482 1066 0.48574
¬d3p14.2 & dXq22.3   d17p11.2 GDSC PANCAN AZD7762 1022 0.29631
¬d(CACNA1D,WNT5A),d3p21.1 & dXq28 & ¬d21q11.2   MLL2 GDSC PANCAN AZD8055 1059 0.4414
¬TP53 & dXq28 | BRAF & ¬a(ARFGAP1,GNAS)   FLT3 GDSC PANCAN BAY_61-3606 178 0.34328
TP53 & d(BNC2,CDKN2A,JAK2,PSIP1) & ¬dXq22.3   d(SMAD4),d18q21.2 GDSC PANCAN BI-2536 60 0.39899
¬d8p21.1 & ¬d16q23.1 & dXp22.32   a(CCNE1) GDSC PANCAN Bicalutamide 1502 0.52098
MACF1 | d(FGFR3),d4p16.3 | d20p12.1 | d15q25.2   d(FGFR3),d4p16.3 GDSC PANCAN BIRB_0796 1042 0.4563
MLL2 | JAK-STAT-UP   JAK-STAT-UP GDSC PANCAN BIX02189 279 0.3094
CASP8 | NF2 | SMARCA4 | IL-1-UP   SMARCA4 GDSC PANCAN Bleomycin__50_uM 1378 0.43608
¬BRAF & ¬TP53 & ¬d(SYNCRIP,ZNF292)   d8p23.1 GDSC PANCAN Bleomycin 190 0.44107
EWSR1-FLI1 | TLR-DOWN   EWSR1-FLI1 GDSC PANCAN BMN-673 1259 0.39321
TET2 | JAK-STAT-UP | IL-1-DOWN | MAPK_only-DOWN   JAK-STAT-UP GDSC PANCAN BMS-345541 203 0.32696
¬MLL2 & ¬d(CHD9,CNOT1,CYLD,MMP2,NUP93) & d(SYNCRIP,ZNF292) & ¬TNFa-DOWN   d(SMAD4),d18q21.2 GDSC PANCAN BMS-509744 63 0.37445
EWSR1-FLI1 & ¬d3q13.33 | ¬TP53 & d(ATRX)   EWSR1-FLI1 GDSC PANCAN BMS-536924 1091 0.46802
¬d(SDHD) & d(BNC2,CDKN2A,JAK2,PSIP1) & dXq21.33   d1p35.3 GDSC PANCAN BMS-708163 1072 0.47961
EWSR1-FLI1 | KRAS   KRAS GDSC PANCAN BMS-754807 184 0.37297
d(SYNCRIP,ZNF292) & ¬dXp21.1 & ¬TNFa-DOWN   d(ARID1B,MAP3K4,MLLT4) GDSC PANCAN Bortezomib 104 0.41969
BCR-ABL | EP300 | a(EGFR)   BCR-ABL GDSC PANCAN Bosutinib 1019 0.44747
¬TP53 & d(ATRX) | a(AHR,HDAC9) & ¬d(BNC2,CDKN2A,JAK2,PSIP1)   BRAF GDSC PANCAN Bryostatin_1 197 0.49276
¬KRAS & ¬d18q22.1 & ¬d(CACNA1D,WNT5A),d3p21.1 & dXq21.33   JAK-STAT-UP GDSC PANCAN BX-795 1037 0.39828
TP53BP1 & ¬d20p12.1 | ¬d3p14.2 & dXq28   JAK-STAT-UP GDSC PANCAN BX-912 222 0.39194
ARID4A | JAK-STAT-UP | MAPK_only-DOWN   MAPK_only-DOWN GDSC PANCAN CAL-101 238 0.34097
JAK-STAT-UP | MAPK_only-DOWN   JAK-STAT-UP GDSC PANCAN CAY10603 276 0.36845
JAK-STAT-UP | MAPK_only-DOWN   JAK-STAT-UP GDSC PANCAN IPA-3 176 0.47467
JAK-STAT-UP | MAPK_only-DOWN   JAK-STAT-UP GDSC PANCAN WZ3105 252 0.35352
d1p36.12 | a20q13.13   a20q13.13 GDSC PANCAN CCT007093 1067 0.40081
PTEN | a(CCND1,CTTN)   PTEN GDSC PANCAN CCT018159 1170 0.44296
¬d3p14.2 & dXq28   JAK-STAT-UP GDSC PANCAN CEP-701 1024 0.44763
¬d3p14.2 & dXq28   JAK-STAT-UP GDSC PANCAN TAK-715 221 0.40708
¬d3p14.2 & dXq28   JAK-STAT-UP GDSC PANCAN TL-2-105 211 0.37704
dXp11.3 & ¬dXq28 | a(EGFR) & ¬a(MET)   a(EGFR) GDSC PANCAN Cetuximab 1114 0.44831
d18q22.1 & ¬dXp11.3   d18q22.1 GDSC PANCAN CGP-082996 54 0.45818
d(BNC2,CDKN2A,JAK2,PSIP1) & d(SYNCRIP,ZNF292)   d(BMPR1A,FAS,PTEN) GDSC PANCAN CGP-60474 53 0.4236
¬d8p23.3 & d(ATRX)   d2q32.1 GDSC PANCAN CH5424802 281 0.47626
¬TP53 & ¬d18q22.1 & ¬d(CASP1),d11q22.3 & ¬a(IL7R)   NF2 GDSC PANCAN CHIR-99021 1241 0.39987
BRAF | NRAS | JAK-STAT-UP   BRAF GDSC PANCAN CI-1040 1015 0.25118
BRAF | NRAS | JAK-STAT-UP   BRAF GDSC PANCAN RDEA119 1014 0.22894
BRAF | NRAS | JAK-STAT-UP   BRAF GDSC PANCAN RDEA119__rescreen 1526 0.232
BRAF | NRAS | JAK-STAT-UP   BRAF GDSC PANCAN VX-11e 262 0.28325
¬TP53 & ¬a(MYC) & ¬d16q23.1   TLR-DOWN GDSC PANCAN Cisplatin 1005 0.35962
¬d(FAT1,IRF2) & ¬d(CHD3,GPS2,TP53) & dXq28 & ¬d(ERCC3)   MAPK_only-DOWN GDSC PANCAN CMK 64 0.2804
¬d3p14.2 & MAPK_only-DOWN | ¬d3p14.2 & dXq28   JAK-STAT-UP GDSC PANCAN CP466722 152 0.32674
¬d(SDHD) & ¬d(ARID1B,MAP3K4,MLLT4) & ¬d17p13.1 & dXq21.33   d(CHD9,CNOT1,CYLD,MMP2,NUP93) GDSC PANCAN Crizotinib 37 0.4735
¬d(BNC2,CDKN2A,JAK2,PSIP1) & dXq22.3   JAK-STAT-UP GDSC PANCAN CUDC-101 273 0.43487
MLL2 | a(MYCN) | JAK-STAT-UP | MAPK_only-DOWN   MLL2 GDSC PANCAN CX-5461 300 0.37184
¬d(CHD3,GPS2,TP53) & dXq28 & ¬d(PABPC3,SACS,ZMYM2)   CREBBP GDSC PANCAN Cyclopamine 17 0.39672
¬TP53 & d(BNC2,CDKN2A,JAK2,PSIP1) & ¬d1p35.3   BCR-ABL GDSC PANCAN Dasatinib 51 0.47322
d(STK11) | d(PCDH18) | a(PIP5K1A,SETDB1) | a(INPP4A)   d(PCDH18) GDSC PANCAN DMOG 165 0.43956
d(FAT1,IRF2) & ¬d17p13.2 & dXp21.1   a(AHR,HDAC9) GDSC PANCAN Docetaxel 1007 0.39402
d18q22.1 & ¬d16q23.1   EWSR1-FLI1 GDSC PANCAN Doxorubicin 133 0.44569
TP53 & ¬a(KRAS) & ¬d(SYNCRIP,ZNF292) & ¬dXp21.1   SMARCA4 GDSC PANCAN EHT_1864 1069 0.46064
EGFR | JAK-STAT-UP   JAK-STAT-UP GDSC PANCAN EKB-569 282 0.41699
¬TP53 & d3p14.2 | d(FAT1,IRF2) & dXq22.3   SMARCA4 GDSC PANCAN Elesclomol 1031 0.4434
¬d(SYNCRIP,ZNF292) & VEGF-UP | ¬d(FAT1,IRF2) & dXq28   BRAF GDSC PANCAN Embelin 172 0.44739
a(MYC) & d(BNC2,CDKN2A,JAK2,PSIP1)   a(MYC) GDSC PANCAN Epothilone_B 201 0.35366
¬d16q23.1 & d2q32.1 | ¬d(BMPR1A,FAS,PTEN) & d3p14.2   d3p14.2 GDSC PANCAN Erlotinib 1 0.46948
¬TP53 & ¬d16q23.1 & ¬H2O2-UP   MLL2 GDSC PANCAN Etoposide 134 0.46332
BRAF | CTNNB1 | d11q24.2 | a(RHEB)   BRAF GDSC PANCAN FH535 173 0.46719
EWSR1-FLI1 | d(CHD9,CNOT1,CYLD,MMP2,NUP93) | MAPK_PI3K-DOWN   a(FGFR1,WHSC1L1) GDSC PANCAN FK866 1248 0.42702
NRAS & ¬d(SDHD) | ¬DDX3X & JAK-STAT-UP   JAK-STAT-UP GDSC PANCAN FMK 231 0.34776
d(MED17) | d5q12.1 | a(CLTC,PPM1D) | a(BCL11A,REL,XPO1)   d(ERCC3) GDSC PANCAN FTI-277 166 0.46672
MLL2 | MAPK_only-DOWN   MAPK_only-DOWN GDSC PANCAN GDC0941__rescreen 1527 0.41109
a(EGFR) & ¬a(RHEB)   a(EGFR) GDSC PANCAN Gefitinib 1010 0.36122
d16q23.1 & ¬d3p14.2   MAPK_only-DOWN GDSC PANCAN Gemcitabine 135 0.45634
a(MYCN) | JAK-STAT-UP | MAPK_only-DOWN | MAPK_PI3K-DOWN   JAK-STAT-UP GDSC PANCAN Genentech_Cpd_10 225 0.36183
ASPM | BCR-ABL | IL-1-DOWN   BCR-ABL GDSC PANCAN GNF-2 52 0.34976
MLL2 | JAK-STAT-UP | MAPK_only-DOWN | TNFa-DOWN   JAK-STAT-UP GDSC PANCAN GSK1070916 226 0.36484
ARID1A | a(RAD21)   a(RAD21) GDSC PANCAN GSK-1904529A 202 0.4664
PTPN11 | XPO1 | JAK-STAT-UP | MAPK_only-DOWN   MAPK_only-DOWN GDSC PANCAN GSK2126458 283 0.41234
¬d8p21.1 & ¬d(SRGAP3) & dXq28   PTEN GDSC PANCAN GSK269962A 1192 0.41853
d19q13.43 | d14q24.1 | JAK-STAT-UP | MAPK_PI3K-DOWN   JAK-STAT-UP GDSC PANCAN GSK429286A 230 0.409
CTNNB1 | FLT3 | XRN1 | a(MYC)   a(MYC) GDSC PANCAN GSK-650394 177 0.3926
PIK3CA | PTEN | JAK-STAT-UP | MAPK_only-DOWN   PTEN GDSC PANCAN GSK690693 326 0.3599
MLL2 | d12p12.3 | a(MACF1)   d12p12.3 GDSC PANCAN GW-2580 193 0.44045
¬TP53 & ¬d8p23.3 & ¬d(FAT1,IRF2)   d20p12.1 GDSC PANCAN GW_441756 1023 0.41952
d16q23.1 & ¬dXp21.1 | d(BNC2,CDKN2A,JAK2,PSIP1) & JAK-STAT-UP   a(KRAS) GDSC PANCAN GW843682X 87 0.28978
EWSR1-FLI1 | XRN1 | a(MYCN)   a(MYCN) GDSC PANCAN HG-5-113-01 1142 0.4284
¬d3p22.1 & d(ATRX) & ¬d(ERCC3)   a2p24.1 GDSC PANCAN HG-5-88-01 1143 0.40558
ASXL1 & ¬d(FAT1,IRF2) | ¬d3p14.2 & dXq28   d(CHD3,GPS2,TP53) GDSC PANCAN HG-6-64-1 159 0.39809
MLL2 | JAK-STAT-UP | MAPK_only-DOWN   JAK-STAT-UP GDSC PANCAN I-BET_151 275 0.29529
MLL2 | JAK-STAT-UP | MAPK_only-DOWN   JAK-STAT-UP GDSC PANCAN KIN001-244 287 0.27283
MLL2 | JAK-STAT-UP | MAPK_only-DOWN   JAK-STAT-UP GDSC PANCAN NPK76-II-72-1 257 0.28625
MLL2 | JAK-STAT-UP | MAPK_only-DOWN   JAK-STAT-UP GDSC PANCAN PIK-93 303 0.31112
MLL2 | JAK-STAT-UP | MAPK_only-DOWN   JAK-STAT-UP GDSC PANCAN QL-XI-92 329 0.40699
MLL2 | JAK-STAT-UP | MAPK_only-DOWN   JAK-STAT-UP GDSC PANCAN Y-39983 309 0.36811
BCR-ABL   BCR-ABL GDSC PANCAN Imatinib 34 0.36565
EZH2 | NF2 | PTEN   PTEN GDSC PANCAN IOX2 1230 0.46583
¬TP53 & ¬d18q22.1 & ¬d3p14.2   JAK-STAT-UP GDSC PANCAN JNJ-26854165 1133 0.35041
¬d18q21.31 & d16q23.1 & d(BNC2,CDKN2A,JAK2,PSIP1) & ¬TGFB-UP   d20p12.1 GDSC PANCAN JNK-9L 157 0.42071
¬d(BNC2,CDKN2A,JAK2,PSIP1) & a(IL7R) | d(MED17) & d(BNC2,CDKN2A,JAK2,PSIP1)   a(IL7R) GDSC PANCAN JNK_Inhibitor_VIII 1043 0.51602
¬TP53 & dXq28 | d(MED17) & ¬dXp21.1   d(MED17) GDSC PANCAN JQ12 164 0.40958
JAK-STAT-UP | TLR-UP | Wnt-UP | MAPK_PI3K-DOWN   JAK-STAT-UP GDSC PANCAN JQ1 1218 0.35917
MLL2 | JAK-STAT-UP | MAPK_only-DOWN   MAPK_only-DOWN GDSC PANCAN JW-7-24-1 256 0.37649
d22q11.1 | d(ING1,IRS2,TFDP1) | PI3K_only-UP   a8q24.13 GDSC PANCAN JW-7-52-1 83 0.46045
d8p23.3 & ¬d(SYNCRIP,ZNF292)   d8p23.1 GDSC PANCAN KIN001-055 288 0.48571
JAK-STAT-UP | H2O2-DOWN | MAPK_only-DOWN   MAPK_only-DOWN GDSC PANCAN KIN001-102 228 0.32557
¬d18q22.1 & ¬d(CASP1),d11q22.3 & ¬d(CHD9,CNOT1,CYLD,MMP2,NUP93) & dXp21.1   a(DHX9) GDSC PANCAN KIN001-135 91 0.46566
XPO1 | JAK-STAT-UP | MAPK_only-DOWN | MAPK_PI3K-DOWN   JAK-STAT-UP GDSC PANCAN KIN001-236 286 0.3657
MLL2 | JAK-STAT-UP | TLR-UP | MAPK_only-DOWN   JAK-STAT-UP GDSC PANCAN KIN001-260 290 0.34711
PCSK5 | d(CACNA1D,WNT5A),d3p21.1 | JAK-STAT-UP   JAK-STAT-UP GDSC PANCAN KIN001-266 291 0.48737
¬d(SMAD4),d18q21.2 & ¬d(CACNA1D,WNT5A),d3p21.1 & dXq28   Wnt-UP GDSC PANCAN KIN001-270 345 0.41342
MLL2 | TET2   TET2 GDSC PANCAN KU-55933 1030 0.44364
TP53 & d18q22.1 & ¬d(BMPR1A,FAS,PTEN)   d(SMAD4),d18q21.2 GDSC PANCAN Lapatinib 119 0.41335
MLL-AFF1 | d(CHD3,GPS2,TP53) | JAK-STAT-UP | MAPK_only-DOWN   JAK-STAT-UP GDSC PANCAN LAQ824 200 0.41714
d16q23.1 & ¬a(KRAS) & ¬d4q22.1 & ¬d21q11.2   d(ATP1A1,CSDE1,NRAS) GDSC PANCAN Lenalidomide 1020 0.36261
¬d18q21.31 & dXq28 & ¬d21q11.2   SMARCA4 GDSC PANCAN LFM-A13 192 0.50971
¬d3p14.1 & MAPK_only-DOWN | BRCA2 & ¬POLR2B   MLL2 GDSC PANCAN LY317615 229 0.47894
¬d3p14.2 & dXq28 & ¬d21q11.2   JAK-STAT-UP GDSC PANCAN Masitinib 292 0.32762
MLL2 | JAK-STAT-UP | TLR-UP | MAPK_PI3K-DOWN   JAK-STAT-UP GDSC PANCAN Methotrexate 1008 0.3207
a(CHD9,CYLD) | a(RHEB) | d(ARID1B,MAP3K4,MLLT4) | VEGF-UP   a(MET) GDSC PANCAN MG-132 9 0.4007
¬d(FAT1,IRF2) & dXq22.3   TGFB-UP GDSC PANCAN Midostaurin 153 0.39933
¬d18q22.1 & ¬d8p23.3 & d(BNC2,CDKN2A,JAK2,PSIP1) & ¬d(SYNCRIP,ZNF292)   MAPK_only-UP GDSC PANCAN Mitomycin_C 136 0.49386
¬d18q22.1 & d16q23.1 & ¬d(FAT1,IRF2)   H2O2-DOWN GDSC PANCAN MK-2206 1053 0.46222
¬d(ARID1B,MAP3K4,MLLT4) & ¬d3p22.1 & d3p14.2   d(ERCC3) GDSC PANCAN MLN4924 1529 0.48334
¬TP53 & d(BNC2,CDKN2A,JAK2,PSIP1) & ¬d(ARID1B,MAP3K4,MLLT4) & ¬H2O2-UP   d(RPL22) GDSC PANCAN MP470 293 0.47186
EWSR1-FLI1 | d7q31.1 | a(PIP5K1A,SETDB1) | a(MDM4,PIK3C2B,ZC3H11A)   TGFB-DOWN GDSC PANCAN MPS-1-IN-1 294 0.40435
d(EXT2) & ¬dXp11.3   d(EXT2) GDSC PANCAN MS-275 88 0.45787
¬KRAS & ¬d3p22.1 & d(ATRX) & ¬d21q11.2   JAK-STAT-UP GDSC PANCAN NG-25 260 0.32455
¬a(CCT5,TERT,TRIO) & ¬d3p14.2 & dXp11.3 & ¬d21q11.2   BCR-ABL GDSC PANCAN Nilotinib 1013 0.31911
¬KRAS & ¬d18q21.31 & d16q23.1 & ¬d21q11.2   d(ING1,IRS2,TFDP1) GDSC PANCAN NSC-207895 269 0.48617
TP53 & ¬d(ARID1B,MAP3K4,MLLT4) & dXp11.3   a(IL7R) GDSC PANCAN NSC-87877 147 0.50508
MLL2 | a(CUL2,EPC1)   MLL2 GDSC PANCAN NU-7441 1038 0.42567
CTNNB1 | ¬TP53   ¬TP53 GDSC PANCAN Nutlin-3a 1047 0.14539
MYH11 | a7q22.1 | VEGF-UP | MAPK_only-DOWN   MYH11 GDSC PANCAN NVP-BEZ235 1057 0.46911
ASXL1 | MLL2 | JAK-STAT-UP | MAPK_only-DOWN   JAK-STAT-UP GDSC PANCAN NVP-BHG712 295 0.2877
d16q23.1 & ¬d(ERCC3) & ¬d(PABPC3,SACS,ZMYM2) & ¬TLR-UP   d12q24.32 GDSC PANCAN NVP-TAE684 35 0.41038
BRAF | a(CCND1,CTTN)   BRAF GDSC PANCAN Obatoclax_Mesylate 182 0.39808
EWSR1-FLI1 | EWSR1-X | TLR-DOWN   EWSR1-FLI1 GDSC PANCAN Olaparib 1495 0.40413
EWSR1-FLI1 | KRAS | NOTCH1 | a(MYCN)   EWSR1-FLI1 GDSC PANCAN OSI-906 185 0.36402
¬d(LARP4B) & ¬d(CACNA1D,WNT5A),d3p21.1 & dXq22.3 & ¬d20p12.1   JAK-STAT-UP GDSC PANCAN OSI-930 298 0.33972
a(MYC) & dXp11.3 | SACS & ¬d8p23.3   EP300 GDSC PANCAN OSU-03012 167 0.44556
¬d(FAT1,IRF2) & ¬d(ARID1B,MAP3K4,MLLT4) & dXq28   JAK-STAT-UP GDSC PANCAN PAC-1 175 0.35209
d18q22.1 & ¬dXq22.3   d18q21.31 GDSC PANCAN Paclitaxel 11 0.21531
MLL2 & ¬a(CCT5,TERT,TRIO)   MLL2 GDSC PANCAN Parthenolide 89 0.44782
CDKN1B | FGFR2 | TGFB-UP   TGFB-UP GDSC PANCAN Pazopanib 199 0.43166
BRAF | KRAS | NRAS   BRAF GDSC PANCAN PD-0325901 1060 0.20236
BRAF | KRAS | NRAS   BRAF GDSC PANCAN Trametinib 1372 0.24008
¬a(MYC) & d(BNC2,CDKN2A,JAK2,PSIP1) & ¬d(FAT1,IRF2) & ¬d3p14.2   JAK-STAT-UP GDSC PANCAN PD-0332991 1054 0.43432
¬d3p14.2 & dXq28   a(BLM,CRTC3,FANCI,IDH2,NR2F2,PCSK6) GDSC PANCAN PD-173074 1049 0.42249
a8q24.13 & ¬a20q13.13   a8q24.13 GDSC PANCAN PF-4708671 1129 0.49534
¬TP53 & dXp21.1 | BRAF & IL-1-UP   BRAF GDSC PANCAN PF-562271 158 0.39091
MLL2 | NCOR2 | d15q14 | JAK-STAT-UP   NRAS GDSC PANCAN PFI-1 1219 0.46285
¬d(SDHD) & ¬d(POT1) & ¬d(SRGAP3) & dXq22.3   TGFB-UP GDSC PANCAN PHA-665752 6 0.42117
MLL2 | TP53BP1 | JAK-STAT-UP | MAPK_only-DOWN   MLL2 GDSC PANCAN PHA-793887 301 0.36643
¬d(CHD3,GPS2,TP53) & dXq28 & ¬d20p12.1   MLL2 GDSC PANCAN Phenformin 196 0.43567
¬TP53 & ¬a(CCT5,TERT,TRIO) & ¬d3p14.2 & ¬TGFB-UP   MLL2 GDSC PANCAN PI-103 302 0.37671
¬a(CCND1,CTTN) & a(EGFR) | BRCA2 & d(ARFGAP3)   a(EGFR) GDSC PANCAN piperlongumine 1243 0.42229
¬d(ARID1B,MAP3K4,MLLT4) & dXq22.3 & ¬d(ERCC3)   MAPK_only-DOWN GDSC PANCAN PXD101_Belinostat 274 0.43653
GATA3 | MECOM | d4q22.1 | MAPK_only-DOWN   MAPK_only-DOWN GDSC PANCAN Pyrimethamine 71 0.39748
¬TP53 & ¬a(MYC) & ¬d3p14.2 & ¬a(MYCN)   d12p13.31 GDSC PANCAN QL-VIII-58 1166 0.45003
¬d(CHD9,CNOT1,CYLD,MMP2,NUP93) & ¬d(FAT1,IRF2) & dXq21.33 & ¬d20p12.1   TNFa-DOWN GDSC PANCAN QL-XII-47 235 0.3972
MACF1 | JAK-STAT-UP | TLR-UP | MAPK_PI3K-DOWN   JAK-STAT-UP GDSC PANCAN QL-XII-61 1203 0.43469
MLL2 & ¬d8p23.3 | ¬d(BNC2,CDKN2A,JAK2,PSIP1) & dXp11.3   d(CHD9,CNOT1,CYLD,MMP2,NUP93) GDSC PANCAN QS11 151 0.39769
¬d(LARP4B) & d(SYNCRIP,ZNF292) & ¬d(RPL22) & ¬d17p13.2   PI3K_only-UP GDSC PANCAN Rapamycin 3 0.40445
TP53 & ¬d(APC) & ¬d17p11.2 & dXp11.3   d(ERCC3) GDSC PANCAN RO-3306 1052 0.46179
d(CASP1),d11q22.3 & d8p23.3 | MLL2 & ¬a(CCT5,TERT,TRIO)   d(PCDH18) GDSC PANCAN Roscovitine 110 0.46839
¬d8p23.1 & ¬d(FAT1,IRF2) & dXq21.33   BRAF GDSC PANCAN rTRAIL 1261 0.47139
¬d(FAT1,IRF2) & ¬d(SRGAP3) & dXq28   MLL2 GDSC PANCAN Salubrinal 111 0.37272
¬d(SYNCRIP,ZNF292) & dXq22.3   a(MYCN) GDSC PANCAN SB_216763 1025 0.3852
¬KRAS & ¬TP53 & ¬d18q22.1 & ¬d(SDHD)   d10q25.3 GDSC PANCAN SB-505124 1194 0.47759
BRAF | EWSR1-FLI1 | MLL3 | TLR-DOWN   d(ARID1B,MAP3K4,MLLT4) GDSC PANCAN SB52334 304 0.41914
d(BMPR1A,FAS,PTEN) & ¬d(FAT1,IRF2) | PTEN & d(BNC2,CDKN2A,JAK2,PSIP1)   d(BMPR1A,FAS,PTEN) GDSC PANCAN SB-715992 208 0.46911
¬d(FAT1,IRF2) & dXp21.1 & ¬d(ERCC3)   PTEN GDSC PANCAN SGC0946 1264 0.43148
¬TP53 & ¬d(MED17) & d(BNC2,CDKN2A,JAK2,PSIP1)   BRAF GDSC PANCAN Shikonin 170 0.48805
¬ARAP3 & a(MYC) | d19q13.33 & IL-1-DOWN   a(MYC) GDSC PANCAN SL_0101-1 1039 0.40248
EWSR1-FLI1 | MLL2 | TLR-DOWN   MLL2 GDSC PANCAN SN-38 1494 0.41095
¬TP53 & ¬a(MYC) & ¬a(IL7R) & ¬d3p14.2   JAK-STAT-UP GDSC PANCAN SNX-2112 328 0.27812
FLT3 | d12p12.3   d12p12.3 GDSC PANCAN Sorafenib 30 0.41912
d(CASP1),d11q22.3 | JAK-STAT-UP | MAPK_only-DOWN | MAPK_PI3K-DOWN   JAK-STAT-UP GDSC PANCAN STF-62247 258 0.35128
¬d3p14.2 & ¬d(CHD3,GPS2,TP53) & dXq28   d(GNAQ,NTRK2,PCSK5,TJP2) GDSC PANCAN S-Trityl-L-cysteine 41 0.43113
¬d(SDHD) & ¬d3p14.2 & dXq22.3   FLT3 GDSC PANCAN Sunitinib 5 0.38379
MLL2 | d7p12.1 | JAK-STAT-UP   MLL2 GDSC PANCAN T0901317 333 0.29003
CREBBP | MLL | PIK3CA | MAPK_only-DOWN   CREBBP GDSC PANCAN Tamoxifen 1199 0.41981
¬APC & ¬a(MYC) & ¬d(BNC2,CDKN2A,JAK2,PSIP1) & ¬d(FAT1,IRF2)   TLR-UP GDSC PANCAN Temozolomide 1375 0.38134
MYH11 | a(ACTB,CARD11,PMS2,RAC1) | d6q23.3 | MAPK_only-DOWN   PTEN GDSC PANCAN Temsirolimus 1016 0.43539
¬d(SMAD4),d18q21.2 & ¬d(ARID1B,MAP3K4,MLLT4) & dXq21.33 & ¬d20p12.1   JAK-STAT-UP GDSC PANCAN TG101348 306 0.37985
MGA | PTEN | d8p21.1 | H2O2-UP   PTEN GDSC PANCAN TGX221 94 0.48654
dXp11.3 & ¬dXq28   a(MYC) GDSC PANCAN Thapsigargin 180 0.41695
EWSR1-X | MLL2 | JAK-STAT-UP | MAPK_only-DOWN   JAK-STAT-UP GDSC PANCAN THZ-2-102-1 346 0.33709
¬d8p23.3 & ¬d16q23.1 & d(SYNCRIP,ZNF292)   BRAF GDSC PANCAN THZ-2-49 344 0.3486
¬TP53 & ¬d8p23.3 & ¬a3q26.1 & ¬d(RPL22)   MLL2 GDSC PANCAN Tipifarnib 204 0.41971
ARID4A & ¬PIK3R1 | ¬d3p14.2 & dXq28   JAK-STAT-UP GDSC PANCAN TL-1-85 261 0.26795
MLL2 | JAK-STAT-UP | TLR-UP   JAK-STAT-UP GDSC PANCAN TPCA-1 305 0.32479
MLL2 | NRAS | JAK-STAT-UP | MAPK_only-DOWN   JAK-STAT-UP GDSC PANCAN Tubastatin_A 265 0.37242
NCOR1 | PTEN | SMARCA4 | TLR-DOWN   PTEN GDSC PANCAN TW_37 1149 0.30998
JAK-STAT-UP | Wnt-UP | MAPK_PI3K-DOWN | TLR-DOWN   MAPK_PI3K-DOWN GDSC PANCAN UNC0638 1236 0.50031
¬d(BNC2,CDKN2A,JAK2,PSIP1) & dXp11.3 | ¬d(CASP1),d11q22.3 & d17p13.1   MLL2 GDSC PANCAN UNC1215 1262 0.41725
¬d(FAT1,IRF2) & JAK-STAT-UP | ¬TP53 & d16q23.1   MLL2 GDSC PANCAN Vinblastine 1004 0.46059
d16q23.1 & ¬d(ATRX)   BRAF GDSC PANCAN Vinorelbine 140 0.45296
¬d8p23.3 & ¬d(SRGAP3) & dXq21.33 & ¬d21q11.2   MLL2 GDSC PANCAN Vismodegib 1033 0.43642
CDKN1B | TET2 | JAK-STAT-UP | MAPK_only-DOWN   JAK-STAT-UP GDSC PANCAN VNLG124 271 0.27355
¬TP53 & dXp22.32   JAK-STAT-UP GDSC PANCAN Vorinostat 1012 0.41712
¬d(POT1) & ¬d4q22.1 & dXq28 & ¬d(PABPC3,SACS,ZMYM2)   MLL2 GDSC PANCAN VX-680 32 0.44535
HLA-A | JAK-STAT-UP | TLR-UP | TNFa-DOWN   JAK-STAT-UP GDSC PANCAN VX-702 1028 0.44645
BCR-ABL | CREBBP | NF2   BCR-ABL GDSC PANCAN WH-4-023 56 0.45062
TP53 & d18q22.1 & ¬dXq22.3   d21q11.2 GDSC PANCAN WZ-1-84 59 0.44998
a(MECOM) | d20p12.1   a(MECOM) GDSC PANCAN XAV_939 1268 0.50353
JAK-STAT-UP & ¬IL-1-DOWN | ¬d(SYNCRIP,ZNF292) & dXq22.3   JAK-STAT-UP GDSC PANCAN XL-184 249 0.42741
¬d3p14.2 & dXq22.3 | ¬ACVR2A & MLL-AFF1   JAK-STAT-UP GDSC PANCAN XL-880 308 0.40562
d(ARID1B,MAP3K4,MLLT4) | JAK-STAT-UP   JAK-STAT-UP GDSC PANCAN XMD11-85h 1158 0.36116
MLL2 | JAK-STAT-UP | IL-1-DOWN | MAPK_only-DOWN   MLL2 GDSC PANCAN XMD13-2 330 0.37849
CREBBP | JAK-STAT-UP | MAPK_only-DOWN   JAK-STAT-UP GDSC PANCAN XMD14-99 253 0.38096
¬d(SRGAP3) & dXq28   JAK-STAT-UP GDSC PANCAN XMD15-27 332 0.45583
¬d(FAT1,IRF2) & dXq28 & ¬d(RB1)   MAPK_only-DOWN GDSC PANCAN XMD8-85 106 0.41674
EP300 | JAK-STAT-UP   EP300 GDSC PANCAN XMD8-92 1164 0.45401
¬d18q22.1 & d3p14.2   PTEN GDSC PANCAN YK_4-279 1239 0.45971
d(FAT1,IRF2) & ¬dXp22.32 | a(CCNE1) & d16q23.1   d(PCDH18) GDSC PANCAN YM155 268 0.50914
EWSR1-FLI1 | d7p12.1 | Wnt-UP | MAPK_only-DOWN   MAPK_only-DOWN GDSC PANCAN YM201636 310 0.31714
¬KRAS & ¬a(MYC) & ¬d8p21.1 & d(SYNCRIP,ZNF292)   d(CHD9,CNOT1,CYLD,MMP2,NUP93) GDSC PANCAN ZG-10 1161 0.40967
EZH2 | JAK-STAT-UP | MAPK_only-DOWN   JAK-STAT-UP GDSC PANCAN Zibotentan_ZD4054 266 0.37943
¬a(ACTB,CARD11,PMS2,RAC1) & a(AKAP9) | d16q23.1 & d(BNC2,CDKN2A,JAK2,PSIP1)   FN1 GDSC PANCAN Z-LLNle-CHO 45 0.45193
XRN1 | JAK-STAT-UP | MAPK_only-DOWN   XRN1 GDSC PANCAN ZM-447439 1050 0.36187
ASXL1 | MLL2 | JAK-STAT-UP | MAPK_only-DOWN   MAPK_only-DOWN GDSC PANCAN ZSTK474 223 0.33037
d10q23.31   d10q23.31 GDSC SKCM 17-AAG 1026 0.42434
a(FOXP1,MITF) | d10q23.31 | TGFB-DOWN   a(FOXP1,MITF) GDSC SKCM _5Z_-7-Oxozeaenol 1242 0.2389
TGFB-UP | TGFB-DOWN   TGFB-UP GDSC SKCM A-770041 55 0.45164
d16q23.1 & ¬d10q26.3   d16q23.1 GDSC SKCM ABT-888 1018 0.51954
BAZ2B   BAZ2B GDSC SKCM AMG-706 1029 0.5135
BAZ2B   BAZ2B GDSC SKCM BMS-536924 1091 0.5
BAZ2B   BAZ2B GDSC SKCM GW_441756 1023 0.5
BAZ2B   BAZ2B GDSC SKCM Nilotinib 1013 0.5
¬TP53 & ¬d16q23.1 & ¬a(FOXP1,MITF) & ¬Wnt-DOWN   EZH2 GDSC SKCM AS605240 224 0.26181
d4p15.2   d4p15.2 GDSC SKCM ATRA 1009 0.52893
¬BPTF & ¬EP300 & TGFB-UP   TGFB-UP GDSC SKCM AUY922 194 0.49476
¬BPTF & ¬PTEN & ¬d16q23.1 & ¬a(KRAS)   a(FOXP1,MITF) GDSC SKCM AZD6244 1498 0.3129
¬NRAS & ¬d10q23.31 & VEGF-UP & ¬TGFB-DOWN   PTEN GDSC SKCM AZD6482 1066 0.39436
¬CDKN2A & ¬PLCB1 & ¬d10q26.3 & VEGF-UP   TGFB-DOWN GDSC SKCM Bleomycin__50_uM 1378 0.17929
¬d(BNC2,CDKN2A,JAK2,PSIP1) & VEGF-UP   Wnt-DOWN GDSC SKCM BMN-673 1259 0.096439
¬d10q23.31 & TGFB-UP | NRAS & d(BNC2,CDKN2A,JAK2,PSIP1)   NRAS GDSC SKCM BMS-754807 184 0.4893
CLASP2   CLASP2 GDSC SKCM Bortezomib 104 0.5
NCOR1 | STK11 | d(CASP1)   NCOR1 GDSC SKCM Bryostatin_1 197 0.5055
d16p13.3 | d15q15.1 | a(MYC) | IL-1-UP   d15q15.1 GDSC SKCM CCT007093 1067 0.50804
¬NF1 & ¬PTEN & TP53 & ¬a(FOXP1,MITF)   ELF1 GDSC SKCM CEP-701 1024 0.13017
¬ELF1 & TP53 & ¬d(BNC2,CDKN2A,JAK2,PSIP1) & ¬VEGF-UP   CTNNB1 GDSC SKCM Cetuximab 1114 0.38567
¬EZH2 & ¬PTEN & d(BNC2,CDKN2A,JAK2,PSIP1) & ¬MAPK_only-UP   d17p13.2 GDSC SKCM CI-1040 1015 0.52973
¬ZNF638 & TGFB-UP & ¬TNFa-UP & ¬Wnt-DOWN   EP300 GDSC SKCM Cisplatin 1005 0.40625
EZH2 | d14q32.2 | TGFB-UP   TGFB-UP GDSC SKCM CX-5461 300 0.39216
BRAF & ¬MAPK_only-UP   BRAF GDSC SKCM Dabrafenib 1373 0.18342
d(BNC2,CDKN2A,JAK2,PSIP1) & ¬d11q24.2 | MECOM & ¬d22q13.31   TGFB-UP GDSC SKCM Dasatinib 51 0.28454
¬ZNF638 & ¬H2O2-UP & TGFB-UP   TGFB-UP GDSC SKCM Doxorubicin 133 0.44484
¬d16p13.3 & d10q23.31 & ¬H2O2-UP   d10q23.31 GDSC SKCM Embelin 172 0.39091
¬NF1 & TP53 & ¬a(FOXP1,MITF) & ¬VEGF-UP   d14q32.2 GDSC SKCM EX-527 341 0.33248
¬ARID1B & ¬STK11 & d(CASP1)   d(CASP1) GDSC SKCM FH535 173 0.49011
EP300 | FAM123B | PTEN | TAOK1   PTEN GDSC SKCM FMK 231 0.45846
ARHGAP29 | EP300 | MLL3 | TAOK1   MCM8 GDSC SKCM FR-180204 263 0.5
¬TP53 & d16q23.1   HDAC9 GDSC SKCM FTI-277 166 0.53002
¬BRAF & d16q23.1 | NF1 & ¬TP53   ARID2 GDSC SKCM GSK-1904529A 202 0.35438
CLASP2 | EP300 | d16p13.3 | TNFa-UP   TGFB-UP GDSC SKCM GSK269962A 1192 0.28172
BRAF & TP53 & ¬d16q23.1 & ¬Wnt-DOWN   a(NOTCH2) GDSC SKCM IOX2 1230 0.49856
NRAS & d(BNC2,CDKN2A,JAK2,PSIP1) & ¬d(CASP1)   BAP1 GDSC SKCM JNK-9L 157 0.52165
ANK3 | BAZ2B | EP300   BAZ2B GDSC SKCM JNK_Inhibitor_VIII 1043 0.5
EZH2 & ¬PCDH18 | d10q26.3 & VEGF-UP   d10q26.3 GDSC SKCM KIN001-260 290 0.53817
EZH2 & ¬LRP6 & ¬MAP3K4   RAC1 GDSC SKCM KIN001-266 291 0.5
BRAF & ¬TP53 & ¬d16q23.1 & ¬VEGF-UP   AHCTF1 GDSC SKCM LAQ824 200 0.43302
¬NRAS & PLCB1 | d(BNC2,CDKN2A,JAK2,PSIP1) & TGFB-UP   TGFB-UP GDSC SKCM Lenalidomide 1020 0.5021
d(BNC2,CDKN2A,JAK2,PSIP1) & H2O2-UP | ARID2 & ¬d16q23.1   ARID2 GDSC SKCM Masitinib 292 0.17018
¬ARID2 & ¬MECOM & d(BNC2,CDKN2A,JAK2,PSIP1)   PLCB1 GDSC SKCM MG-132 9 0.2628
BPTF | MAP3K4 | TGFB-DOWN | Wnt-DOWN   CDKN2A GDSC SKCM NSC-87877 147 0.47434
¬TP53 & ¬d(CASP1) | CDKN2A & d(BNC2,CDKN2A,JAK2,PSIP1)   ARID2 GDSC SKCM Nutlin-3a 1047 0.18384
¬ARHGAP29 & EZH2 | ¬d10q23.31 & TGFB-UP   EZH2 GDSC SKCM Obatoclax_Mesylate 182 0.42639
BAZ2B | EP300 | RB1 | d16q23.1   d16q23.1 GDSC SKCM Olaparib 1495 0.17222
EP300 | NCOR1 | IL-1-UP   ARID2 GDSC SKCM OSI-906 185 0.5
DHX15 | FAM123B | PI3K_only-DOWN   H2O2-UP GDSC SKCM Pazopanib 199 0.50987
¬PCDH18 & ¬PTEN & d(BNC2,CDKN2A,JAK2,PSIP1)   NRAS GDSC SKCM PD-0325901 1060 0.27808
ELF1 | FAM123B | PTEN | ZNF638   FAM123B GDSC SKCM PF-4708671 1129 0.51837
CLSPN | PTEN   PTEN GDSC SKCM PFI-1 1219 0.47438
STK11 & d(BNC2,CDKN2A,JAK2,PSIP1) | EZH2 & ¬PCDH18   EZH2 GDSC SKCM Phenformin 196 0.50409
¬a(FOXP1,MITF) & TGFB-UP & ¬Wnt-DOWN   TGFB-UP GDSC SKCM piperlongumine 1243 0.51428
d(PAX5) | a(FOXP1,MITF) | TGFB-UP | TGFB-DOWN   a(FOXP1,MITF) GDSC SKCM PLX4720 1036 0.28779
BRAF & ¬d10q26.3 & ¬H2O2-UP   TGFB-DOWN GDSC SKCM PLX4720__rescreen 1371 0.17679
¬PLCB1 & ¬TP53 & ¬d16q23.1 & ¬Wnt-DOWN   VEGF-UP GDSC SKCM QL-XII-61 1203 0.52495
a(FOXP1,MITF)   a(FOXP1,MITF) GDSC SKCM RDEA119 1014 0.36062
a(FOXP1,MITF)   a(FOXP1,MITF) GDSC SKCM RDEA119__rescreen 1526 0.43614
PTEN | d17p13.2 | TGFB-UP   TGFB-UP GDSC SKCM rTRAIL 1261 0.37722
TGFB-UP   TGFB-UP GDSC SKCM SB_216763 1025 0.50635
CEP290 | MLL3 | PCDH18 | d4p15.2   CEP290 GDSC SKCM SB-505124 1194 0.41422
RAC1 | d14q32.2   d14q32.2 GDSC SKCM SB52334 304 0.56621
BRAF & ¬MAPK_only-UP & ¬TNFa-UP   a(FOXP1,MITF) GDSC SKCM SB590885 1061 0.28168
VEGF-UP & Wnt-DOWN   Wnt-DOWN GDSC SKCM SGC0946 1264 0.53875
¬MECOM & ¬TP53 & d16q23.1 & ¬d10q23.33   d16q23.1 GDSC SKCM Shikonin 170 0.54085
BAZ2B | EP300   BAZ2B GDSC SKCM Temsirolimus 1016 0.53303
BRAF & ¬a(MDM2,NUP107) & ¬TGFB-DOWN & ¬Wnt-DOWN   ZNF638 GDSC SKCM TGX221 94 0.54849
ANK3 & d17p13.2 | ARID2 & ¬NF1   ARID2 GDSC SKCM Tipifarnib 204 0.42283
¬KDM6A & ¬MAPK_only-UP & ¬TNFa-UP & ¬Wnt-DOWN   a(FOXP1,MITF) GDSC SKCM Trametinib 1372 0.36264
EZH2 | TGFB-UP   EZH2 GDSC SKCM Tubastatin_A 265 0.50157
CEP290 | MAP3K4 | PTEN | a(MYC)   CDKN2A GDSC SKCM TW_37 1149 0.39893
TP53 & ¬d11q24.2 & ¬a(MYC)   a(NOTCH2) GDSC SKCM UNC0638 1236 0.24146
BRAF & ¬TP53 & TGFB-UP   EP300 GDSC SKCM Vismodegib 1033 0.4593
EP300 | EZH2 | Wnt-DOWN   EZH2 GDSC SKCM VX-11e 262 0.43812
d16q23.1 | a(MYC)   d16q23.1 GDSC SKCM VX-702 1028 0.18126
NCOR1   NCOR1 GDSC SKCM XMD14-99 253 0.5009
TP53 & ¬d16q23.1 & ¬a(FOXP1,MITF) & ¬d(CASP1)   TGFB-UP GDSC SKCM Y-39983 309 0.38321
ATR | MYH9 | d19p13.2   PIK3CA GDSC STAD 17-AAG 1026 0.49209
¬NF1 & ¬d6p25.2 & ¬d20p12.1 & ¬d(FAT1,IRF2)   CTNNB1 GDSC STAD ABT-263 1011 0.39279
¬APC & ¬ARID1A & ¬d6q25.1 & d3p14.2   d(MAP2K4) GDSC STAD Afatinib 1032 0.16594
¬d(CDKN2A) & d20p12.1   PIK3CA GDSC STAD AKT_inhibitor_VIII 171 0.34245
d16q23.1 & ¬PI3K_only-DOWN   d16q23.1 GDSC STAD CX-5461 300 0.1662
¬ARID2 & ¬d6p25.3 & ¬a(MET) & ¬d4q22.1   d19p13.2 GDSC STAD EHT_1864 1069 0.31226
ARID1A & ¬d16q23.1   ARID1A GDSC STAD GSK-1904529A 202 0.54449
MET | TLR-UP | IL-1-DOWN   IL-1-DOWN GDSC STAD GSK690693 326 0.44254
MYH9 | TP53BP1 | d(MAP2K4) | d(PTEN)   d(MAP2K4) GDSC STAD MK-2206 1053 0.39699
d19p13.2 & ¬a(MET) | a(MYC) & ¬a(FOXA2)   a(MYC) GDSC STAD PF-4708671 1129 0.1627
¬CTNNB1 & ¬d16q23.1 & ¬d14q11.2   ¬d16q23.1 GDSC STAD rTRAIL 1261 0.24383
d22q13.31   d22q13.31 GDSC STAD Trametinib 1372 0.37657
¬TP53 | a(STK4) | d(PTEN)   ¬TP53 GDSC STAD Y-39983 309 0.22979
BRAF & ¬NF2   PIK3CA GDSC THCA _5Z_-7-Oxozeaenol 1242 0.13753
BRAF & ¬NF2 & ¬IL-1-UP   PIK3CA GDSC THCA AZD6244 1498 0.15282
NF2 | PIK3CA | SMARCA4   CREBBP GDSC THCA Bleomycin__50_uM 1378 0.36795
¬BRAF & ¬NRAS & ¬H2O2-UP   d(FANCG,PAX5) GDSC THCA Bryostatin_1 197 0.14031
¬d(FANCG,PAX5) & PI3K_only-DOWN | IL-1-UP   IL-1-UP GDSC THCA CHIR-99021 1241 0.5
KRAS | NRAS | PIK3CA | SMARCA4   PIK3CA GDSC THCA CI-1040 1015 0.33522
CREBBP | NRAS   NRAS GDSC THCA CX-5461 300 0.54203
KRAS | BRAF   BRAF GDSC THCA Dabrafenib 1373 0.00098641
¬d(FANCG,PAX5) & ¬BRAF & ¬NRAS & ¬H2O2-UP   CREBBP GDSC THCA FTI-277 166 0.32424
NF2 | SMARCA4 | TGFB-UP | PI3K_only-DOWN   NF2 GDSC THCA IOX2 1230 0.5
NRAS & ¬TGFB-DOWN | BRAF & ¬IL-1-UP   NRAS GDSC THCA PD-0325901 1060 0.32652
BRAF & ¬NF2   BRAF GDSC THCA PLX4720 1036 0.029607
BRAF & ¬NF2   BRAF GDSC THCA PLX4720__rescreen 1371 0.10641
BRAF & ¬IL-1-UP | PTEN & ¬NF1   PIK3CA GDSC THCA RDEA119__rescreen 1526 0.14327
¬BRAF & NRAS | ¬KRAS & NF2   NRAS GDSC THCA Thapsigargin 180 0.25099
BRAF & ¬NRAS   BRAF GDSC THCA Trametinib 1372 0.1188